Allergy Asthma Immunol Res.  2019 May;11(3):306-319. 10.4168/aair.2019.11.3.306.

Influence of Intranasal Drugs on Human Nasal Mucociliary Clearance and Ciliary Beat Frequency

• Jiao J
• Zhang L

• KMID: 2442043
• DOI: http://doi.org/10.4168/aair.2019.11.3.306

Abstract

The nasal mucociliary clearance system, which comprises epithelial cilia and mucus from goblet cells, is an important intrinsic defense mechanism of the upper respiratory tract. Intranasal drugs and additives can have a detrimental effect on ciliary activity and mucociliary clearance, and thus impact the integrity of nasal defense mechanisms. This article discusses the current literature on the effects of different classes of intranasal drugs including intranasal corticosteroids, antihistamines, decongestants, antimicrobials and antivirals, as well as various drug excipients and nasal irrigation solutions on human nasal mucociliary clearance and ciliary beat frequency. Available data indicate that some intranasal formulations tend to hamper nasal ciliary function and mucociliary clearance. Therefore, it is of great importance to assess the effects of intranasal drugs and additives on mucociliary function before they are recommended as therapy for different nasal conditions.

Keyword

Intranasal administration; excipients; nasal irrigations; mucociliary clearances; cilia

MeSH Terms

Administration, Intranasal
Adrenal Cortex Hormones
Antiviral Agents
Cilia
Defense Mechanisms
Excipients
Goblet Cells
Histamine Antagonists
Humans*
Mucociliary Clearance*
Mucus
Nasal Decongestants
Nasal Lavage
Respiratory System
Adrenal Cortex Hormones
Antiviral Agents
Excipients
Histamine Antagonists
Nasal Decongestants

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