J Gynecol Oncol.  2019 May;30(3):e46. 10.3802/jgo.2019.30.e46.

Immunotherapy in endometrial cancer: new scenarios on the horizon

• Di Tucci C
• Capone C
• Galati G
• Iacobelli
• Schiavi MC
• Di Donato
• Muzii L
• Panici PB

• KMID: 2440518
• DOI: http://doi.org/10.3802/jgo.2019.30.e46

Abstract

This extensive review summarizes clinical evidence on immunotherapy and targeted therapy currently available for endometrial cancer (EC) and reports the results of the clinical trials and ongoing studies. The research was carried out collecting preclinical and clinical findings using keywords such as immune environment, tumor infiltrating lymphocytes, programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) expression, immune checkpoint inhibitors, anti-PD-1/PD-L1 antibodies and others' on PubMed. Finally, we looked for the ongoing immunotherapy trials on ClinicalTrials.gov. EC is the fourth most common malignancy in women in developed countries. Despite medical and surgical treatments, survival has not improved in the last decade and death rates have increased for uterine cancer in women. Therefore, identification of clinically significant prognostic risk factors and formulation of new rational therapeutic regimens have great significance for enhancing the survival rate and improving the outcome in patients with advanced or metastatic disease. The identification of genetic alterations, including somatic mutations and microsatellite instability, and the definition of intracellular signaling pathways alterations that have a major role in in tumorigenesis is leading to the development of new therapeutic options for immunotherapy and targeted therapy.

Keyword

Endometrial Cancer; Immunotherapy; Biological Therapy; Molecular Targeted Therapy

MeSH Terms

Antibodies
Biological Therapy
Carcinogenesis
Developed Countries
Endometrial Neoplasms*
Female
Humans
Immunotherapy*
Lymphocytes, Tumor-Infiltrating
Microsatellite Instability
Molecular Targeted Therapy
Mortality
Risk Factors
Survival Rate
Uterine Neoplasms
Antibodies