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Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation

Rho SB, Byun HJ, Kim BR, Lee CH

Metformin is an anti-diabetic drug and has anticancer effects on various cancers. Several studies have suggested that metformin reduces cell proliferation and stimulates cell-cycle arrest and apoptosis. However, the definitive...
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Rate of premalignant and malignant endometrial lesion in “low-risk” premenopausal women with abnormal uterine bleeding undergoing endometrial biopsy

Jha S, Singh A, Sinha HH, Bhadani P, Anant M, Agarwal M

Objective To determine the incidence of endometrial hyperplasia and endometrial cancer (EH/EC) in low-risk premenopausal women with abnormal uterine bleeding (AUB) undergoing endometrial biopsy and to build a predictive model that...
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Stage one endometrioid endometrial adenocarcinoma: is there a role of traditional hospital follow-up in the detection of cancer recurrence in women after treatment?

Nikolopoulos M, Godfrey MA, Sohrabi F, Wong M, Bhatte D, Wuntakal R

Objective To investigate the rate of asymptomatic recurrence of stage 1 endometrioid endometrial cancer and assess the role of routine hospital follow-up after treatment. Methods We performed a retrospective case-note review...
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Vaginal cancer as a late complication of radiotherapy for endometrial cancer and ileo-perineal fistula after total pelvic exenteration

Comba C, Topaktas M, Bozkurt H, Erbin A, Ozdogan B, Demir O

Pelvic exenteration is a highly morbid operation and remains one of the most catastrophic surgical procedures in gynecological oncology. We would like to present the case of total pelvic exenteration...
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A phase II, open-labeled, single-arm study of dose-dense paclitaxel plus carboplatin in advanced or recurrent uterine endometrial cancer treatment: a KCOG-G1303, DOENCA trial

Hori K, Nishio S, Ushijima K, Kasamatsu Y, Kondo E, Takehara K, Ito K

Objective To determine the safety and efficacy of dose-dense (dd) paclitaxel (PTX) and carboplatin (CBDCA) in treating advanced or recurrent endometrial cancer. Methods Women aged 20–75 years with histologically confirmed endometrial cancer, the...
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Concordance between preoperative ESMO-ESGO-ESTRO risk classification and final histology in early-stage endometrial cancer

Daix M, Angeles MA, Migliorelli F, Kakkos A, Gomez CM, Delbecque K, Mery E, Tock S, Gabiache E, Decuypere M, Goffin F, Martinez A, Ferron G, Kridelka F

Objective To evaluate the concordance between preoperative European Society for Medical Oncology (ESMO)-European Society of Gynaecological Oncology (ESGO)-European SocieTy for Radiotherapy and Oncology (ESTRO) risk classification in early-stage endometrial cancer (EC)...
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Practical issues and research trends of oncofertility in gynecologic cancer

Park JY

In recent years, there has been a greater impetus toward preserving fertility in young women with gynecologic cancer. This is related to the increasing incidence of gynecologic cancer in young...
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Laparoscopic vs. robotic-assisted laparoscopy in endometrial cancer staging: large retrospective singleinstitution study

Perrone E, Capasso I, Pasciuto T, Gioè A, Alletti SG, Restaino S, Scambia G, Fanfani F

Objective: The aim of this study is to analyze and draw the potential differences between the robotic-assisted surgery (RS) and the laparoscopy (LPS) in endometrial cancer staging. Methods: In this single-institution...
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Identification of an immune-related risk signature and nomogram predicting the overall survival in patients with endometrial cancer

Cheng Y, Li X, Dai Y, Dong Y, Yang X, Wang J

Objective: Aimed to construct an immune-related risk signature and nomogram predicting endometrial cancer (EC) prognosis. Methods: An immune-related risk signature in EC was constructed using the least absolute shrinkage and selection...
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The application of machine learning for predicting recurrence in patients with early-stage endometrial cancer: a pilot study

Akazawa M, Hashimoto K, Noda K, Yoshida K

Objective Most women with early stage endometrial cancer have a favorable prognosis. However, there is a subset of patients who develop recurrence. In addition to the pathological stage, clinical and therapeutic...
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Substantial lymph-vascular space invasion (LVSI) as predictor of distant relapse and poor prognosis in low-risk early-stage endometrial cancer

Tortorella L, Restaino S, Zannoni GF, Vizzielli G, Chiantera V, Cappuccio S, Gioè A, Fera EL, Dinoi G, Angelico G, Scambia G, Fanfani F

Objective: The aim of this study is to analyze the prognostic role of lymph-vascular space invasion (LVSI), evaluated in a semi-quantitative fashion on prognosis of early stage, low risk endometrial...
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Recurrence risk factors in stage IA grade 1 endometrial cancer

Nwachukwu C, Baskovic M, Eyben RV, Fujimoto D, Giaretta S, English D, Kidd E

Objectives: Patients with early-stage endometrial cancers (EC) with disease recurrences have worse survival outcomes. The purpose of this study was to identify clinical and pathologic factors that predict for all...
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Lymphadenectomy issues in endometrial cancer

Konno Y, Asano H, Shikama A, Aoki D, Tanikawa M, Oki A, Horie K, Mitsuhashi A, Kikuchi A, Tokunaga H, Terao Y, Satoh T, Ushijima K, Ishikawa M, Yaegashi N, Watari H

Objectives: This review aims to introduce preoperative scoring systems to predict lymph node metastasis (LNM) and ongoing clinical trials to investigate the therapeutic role of lymphadenectomy for endometrial cancer. Methods: We...
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Comparative Survival Outcome of Robot-Assisted Staging Surgery Using Three Robotic Arms versus Open Surgery for Endometrial Cancer

Eoh KJ, Lee DW, Lee JH, Nam EJ, Kim SW, Kim YT

Purpose: There is lack of data on direct comparison of survival outcomes between open surgery and robot-assisted staging surgery (RSS) using three robotic arms for endometrial cancer. The purpose of...
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Impact of lymphadenectomy on the treatment of endometrial cancer using data from the JSOG cancer registry

Saotome K, Yamagami W, Machida H, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Enomoto T, Aoki D, Mikami M

Objective Regional lymph node (LN) dissection is a standard surgical procedure for endometrial cancer, but there is currently no clear consensus on its therapeutic significance. We aimed to determine the...
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Cancer field surgery in endometrial cancer: peritoneal mesometrial resection and targeted compartmental lymphadenectomy for locoregional control

Buderath P, Rusch P, Mach P, Kimmig R

Objective: Peritoneal mesometrial resection (PMMR) plus targeted compartmental lymphadenectomy (TCL) aims at removal of the locoregional cancer field in endometrial cancer (EC). Optimal locoregional control without adjuvant radiotherapy and acceptable...
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Radiation induced pemphigoid disease

Kim J, Jung T, Kim K, Kim K, Hong S, Baek S, Moon J

Among the possible complications of radiation therapy, acute and chronic side effects on the skin can be induced by percutaneous radiotherapy in the target site. Common skin lesions include radiation...
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Management of stage II endometrial cancer and subsequent oncologic outcomes: a National Cancer Database study

Vetter MH, Bixel K, Felix AS

Objective: The management of stage II endometrial cancer (EC) is challenging due to the wide variation in surgical practice and adjuvant treatment recommendations. We sought to describe the treatment patterns...
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Fertility-sparing treatment in early endometrial cancer: current state and future strategies

Obermair A, Baxter E, Brennan DJ, McAlpine JN, Muellerer JJ, Amant F, van Gent MDJM, Coleman RL, Westin SN, Yates MS, Krakstad C, Janda M

Endometrial cancer (EC) is the fifth most common cancer in women worldwide. Global estimates show rising incidence rates in both developed and developing countries. Most women are diagnosed postmenopausal, but...
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Pelvic malakoplakia presenting as endometrial cancer: a case report

Cho JS, Kim HI, Lee JY, Nam EJ, Kim S, Kim YT, Kim SW

Malakoplakia is a rare granulomatous, inflammatory disease generally manifesting as ulcers of the urogenital tract, especially in the bladder, but it can occur in any part of the body. Because...
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