Korean J Pediatr Infect Dis.  1996 Nov;3(2):200-206. 10.14776/kjpid.1996.3.2.200.

A Case of Epstein Barr Virus-Associated Hemophagocytic Syndrome Confirmed by mRNA In Situ Hybridization and Polymerase Chain Reaction

• Kim CH
• Yang CH
• Sohn YM
• Kim H

• KMID: 2440444
• DOI: http://doi.org/10.14776/kjpid.1996.3.2.200

Abstract

Virus associated hemophagocytic syndrome(VAHS), a class II histiocytosis syndrome, is characterized by high fever, liver dysfunction, coagulation abnormalities, and generalized histiocytic proliferation with marked hemophagocytosis in bone marrow and lymph nodes. VAHS is associated with several viral infections including Epstein Barr virus which has a relatively high mortality rate. We report a fatal case of Epstein Barr virus associated hemophagocytic syndrome and its diagnosis by mRNA in situ hybridization and polymerase chain reaction. A brief review of related literaure is also presented.

Keyword

Epstein Barr virus; Virus-associated hemophagocytic syndrome

MeSH Terms

Bone Marrow
Diagnosis
Fever
Herpesvirus 4, Human
Histiocytosis
In Situ Hybridization*
Liver Diseases
Lymph Nodes
Lymphohistiocytosis, Hemophagocytic*
Mortality
Polymerase Chain Reaction*
RNA, Messenger*
RNA, Messenger