Korean J Pediatr Infect Dis.  1998 May;5(1):147-151. 10.14776/kjpid.1998.5.1.147.

Two Cases of Intravenous Immun Globulin Non-responded Kawasaki Disease

• Kim HB
• Cho BS
• Cha SH

• KMID: 2440331
• DOI: http://doi.org/10.14776/kjpid.1998.5.1.147

Abstract

On the treatment of Kawasaki disease, approximately 10% of children treated with IVIG have persistent or recrudescent fever despite IVIG treatment. We had experienced two children with Kawasaki disease who did not respond after multiple dosages of IVIG. They were treated within the first 10 days of onset of fever and were given oral aspirin (100mg/kg/day) and IVIG(2gm/kg) in a single infusion for 8 to 10 hours. The first child had not resolution of symptoms after three intravenous doses of IVIG(total 4gm/kg). And then treated with high dose methylprednisolone(30mg/kg) for 2 to 3 hours intravenously without symptoms improvement. On fifth hospital days, he was retreated with IVIG (2gm/kg) again with ultimate resolution of symptoms. The second child had resolution of symptoms after three intravenous doses of IVIG(total 4gm/kg). No adverse events were associated with the administration of IVIG or steroid. We reported two cases of IVIG non-responded Kawasaki disease with a brief review of the related literatures.

Keyword

Kawasaki disease; Intravenous immune globulin; Corticosteroid

MeSH Terms

Aspirin
Child
Fever
Humans
Immunoglobulins, Intravenous
Mucocutaneous Lymph Node Syndrome*
Aspirin
Immunoglobulins, Intravenous