Yonsei Med J.  1996 Oct;37(5):357-363. 10.3349/ymj.1996.37.5.357.

Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease

• Lee HK
• Kim DS
• Noh GW
• Lee KY

• KMID: 699913
• DOI: http://doi.org/10.3349/ymj.1996.37.5.357

Abstract

The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.

Keyword

Kawasaki disease; intravenous immune globulin; T cell; B cell; CD5+ B cell

MeSH Terms

Child, Preschool
Female
Human
Immunoglobulins, Intravenous/*therapeutic use
Immunophenotyping
Infant
Lymphocyte Subsets/*immunology
Male
Mucocutaneous Lymph Node Syndrome/immunology/*therapy
Support, Non-U.S. Gov't