Korean J Pediatr Infect Dis.  2001 May;8(1):101-106. 10.14776/kjpid.2001.8.1.101.

The Study of Intravenous-gammaglobulin Therapy in Acute phase of Measles

• Kim MS
• Cha YH

• KMID: 2440210
• DOI: http://doi.org/10.14776/kjpid.2001.8.1.101

Abstract

PURPOSE
The outbreaks of measles in infants and school children have been reported recently, but there are no specific treatment of these patients except symptomatic therapy. This study was performed to evaluate the effectiveness of intravenous gammaglobulin(IVGG) therapy in acute febrile phase of measles.
METHODS
The 68 cases in measles were treated with single dose of IVGG(400~500 mg/kg), and 44 cases were treated with only symptomatic treatment during the periods of 14 months from Jan. 2000 to Feb. 2001. They were compared to duration of fever, rash, the levels of CRP and days of admission on both groups after treatment.
RESULTS
The results obtained follows. The average of age was 7.9±3.6 year old, and male to female was 1.0 : 1.6. The duration of fever after admission was 2.4±1.2 days in treated group and 5.7±2.4 days in control group. The period of disappearance of systemic erythematous maculopapular rash was 4.5±1.3 days in treated group, and 6.9±2.4 days in control group. The durations of admission day were also shown significantly shorter duration of period in treated group(P < 0.05). The levels of CRP were no significant difference between two groups before treatment. However, treated group was significantly shown by improved within 5 days after IVGG therapy(P < 0.05).
CONCLUSIONS
The single dose of IVGG(400~500 mg/kg) therapy is one of rapid and effective therapy for clinical symptoms and signs in acute high febrile phase of measles.

Keyword

Measles; Intravenous-gammaglobulin

MeSH Terms

Child
Disease Outbreaks
Exanthema
Female
Fever
Humans
Infant
Male
Measles*