J Korean Child Neurol Soc.
2002 May;10(1):142-149.
High-dose Methylprednisolone Pulse Therapy in Measles Postinfectious Encephalomyelitis: Two Cases of Successful Recovery
- Affiliations
-
- 1Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea. agathac@nhimc.or.kr
- 2Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Kyunggi, Korea.
- 3Department of Diagnostic Radiology, National Health Insurance Corporation Ilsan Hospital, Kyunggi, Korea.
Abstract
- We treated two patients of measles postinfectious encephalomyelitis with intravenous methylprednisolone pulse therapy(1 g/1.73 m2/day for 5 days) 38 hours and 5 days respectively after the onset of neurologic symptoms. Despite extensive white matter involvement shown in MRI and severe clinical symptoms, the patients recovered from their neurologic symptoms dramatically following intravenous methylprednisolone pulse therapy. Because acute postinfectious encephalomyelitis has been postulated to be immunologically mediated disease, instead of direct viral invasion, ACTH and dexamethasone are widely used and the outcome is variable. This case report of successful recovery from fulminant ADEM with pulse intravenous methylprednisolone therapy, although uncontrolled, suggests that this therapeutic regimen should be studied in other cases.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A case of Swyer-James Syndrome Successfully Treated with Methylprednisolone Pulse Therapy
- Immediate Effects of Methylprednisolone Pulse Therapy on the Immune Response
- Infantile hemangioendothelioma treated with high dose methylprednisolone pulse therapy
- A Case of Multiple Sclerosis
- Comparison of Therapeutic Effect of High Dose Corticosteroid Pulse Therapy and Combination Therapy of Cyclosporine with Low Does Corticosteroid for Severe Alopecia Areata
