Korean J Pediatr Infect Dis.  2001 May;8(1):94-100. 10.14776/kjpid.2001.8.1.94.

Clinical Significance of Enterovirus in Febrile Illness of Young Children

• Kwak JY
• Cho MH
• Kim SE
• Kang SH
• Kim MO
• Ma SH
• Lee KM

• KMID: 2440209
• DOI: http://doi.org/10.14776/kjpid.2001.8.1.94

Abstract

PURPOSE
Enterovirus is a common cause of aseptic meningitis and nonspecific febrile illness in young children. During the summer and fall months, enterovirus-infected young children are frequently admitted and evaluated to rule out bacterial sepsis and/or meningitis. The purpose of this study was to evaluate the relationship between nonpolio enterovirus infection and febrile illness in infants under 3 months of age during the summer, fall months by using a stool culture to identify the presence of enterovirus.
METHODS
Patients included febrile infants under 3 months of age admitted to Masan Fatima Hospital for sepsis evaluation from May 1999 to September 1999. Cultures were performed from stool and Cerebrospinal fluid samples and then were tested for enterovirus infection. Viral isolation and serotype identification were performed by cell culture and immunofluorescent testing. Enteroviruses not typed by immunofluorescent testing were confirmed by reverse transcription-polymerase chain reaction.
RESULTS
A total of 44 febrile infants were enrolled; of those, 20(45%) were positive for enterovirus. Two enterovirus culture-positive infants had concomitant urinary tract infection and one had Kawasaki disease. All infants infected with an enterovirus recovered without complications. Serotype of 20 enteroviruses were isolated from stool, 3 of echovirus type 9, 1 of echovirus type 11, 1 Coxsachievirus type B4, 15 of untyped enteroviruses. One untyped enterovirus was isolated in the CSF.
CONCLUSION
Nonpolio enterovirus infections are associated with nonspecific febrile illnesses in infants under 3 months of age.

Keyword

Enterovirus; Febrile illness; Young children

MeSH Terms

Cell Culture Techniques
Cerebrospinal Fluid
Child*
Enterovirus B, Human
Enterovirus Infections
Enterovirus*
Humans
Infant
Meningitis
Meningitis, Aseptic
Mucocutaneous Lymph Node Syndrome
Sepsis
Serogroup
Urinary Tract Infections