Korean J Pediatr Infect Dis.  2004 Nov;11(2):158-169. 10.14776/kjpid.2004.11.2.158.

Clinical Analysis of Influenza in Children and Rapid Antigen Detection Test on First Half of the Year 2004 in Busan

• Choi SY
• Lee NY
• Kim SM
• Kim GH
• Jung JH
• Choi IJ
• Cho KS

• KMID: 2440062
• DOI: http://doi.org/10.14776/kjpid.2004.11.2.158

Abstract

PURPOSE
Although influenza is one of the most important cause of acute respiratory tract infections in children, virus isolation is not popular and there are only a few clinical studies on influenza and diagnostic methods. We evaluated the epidemiological and clinical features of influenza in children and rapid antigen detection test(QuickVue influenza test) on fist half of the year 2004 in Busan.
METHODS
From January 2004 to June 2004, throat swab and nasal secretion were obtained and cultured for the isolation of influenza virus and tested by rapid antigen detection test(QuickVue influenza test) in children with suspected influenza infections. The medical records of patients with influenza virus infection were reviewed retrospectively.
RESULTS
Influenza viruses were isolated in 79(17.2%) out of 621 patients examined. Influenza virus was isolated mainly from March to April 2004. The ratio of male and female with influenza virus infection was 1.2 : 1 with median age of 4 years 6month. The most common clinical diagnosis of influenza virus infection was bronchitis. There was no difference between influenza A and B infection in clinical diagnosis and symptoms. All patients recovered without severe complication. The sensitivity obtained for rapid antigen detection test (QuickVue influenza test) was 93.6% and the specificity was 80.2%, the positive predictive value 40.8%, the negative predictive value 98.8%.
CONCLUSION
With rapid antigen detection test, it is possible early detection of influenza in children. reduction in use of antimicrobial agent and early use of antiviral agent.

Keyword

Influenza in children; Rapid antigen detection yest(QuickVue influenza test)

MeSH Terms

Bronchitis
Busan*
Child*
Diagnosis
Female
Humans
Influenza, Human*
Male
Medical Records
Orthomyxoviridae
Pharynx
Respiratory Tract Infections
Retrospective Studies
Sensitivity and Specificity