Korean J Pediatr Infect Dis.  2007 Nov;14(2):136-144. 10.14776/kjpid.2007.14.2.136.

Clinical manifestation of human bocavirus infection in children

• Choi CS
• Pak CH
• Jung K
• Lee G
• Sun KK
• Kim EY
• Kim KS
• Kim YW
• Seo JJ
• Chung YS

• KMID: 2439946
• DOI: http://doi.org/10.14776/kjpid.2007.14.2.136

Abstract

PURPOSE
Human bocavirus (HBoV) was recently identified world widely in clinical specimens from infants and children with respiratory tract illness, but the role of HBoV in respiratory tract illnesses is unknown. The aim of this study was to investigate the frequency and the clinical manifestation of HBoV in pediatric patients.
METHODS
We retrospectively investigated 1,777 throat swab obtained between 2005 and 2006 from pediatric in-patients with acute respiratory tract diseases at the Kwang-ju Christian Hospital. The medical records of patients with positive results were reviewed for demographic and clinical data of HBoV infections.
RESULTS
HBoV DNA was found in 84 (4.7%) of the 1,777 hospitalized children and the mean age was 19 months. The most common diagnosis were pneumonia (67.8%), bronchiolitis (35.7%). HBoV infections were found year-round, though most occurred in spring and winter months.
CONCLUSION
HBoV is frequently found in hospitalized infants and children with acute respiratory tract diseases in Korea, but an association of HBoV with a distinct respiratory tract manifestation was not apparent. To clarify the clinical significance of HBoV, further evaluation of various age groups and clinical groups is needed.

Keyword

Respiratory infection; Human Bocavirus; Children; Clinical manifestation

MeSH Terms

Bronchiolitis
Child*
Child, Hospitalized
Diagnosis
DNA
Gwangju
Human bocavirus*
Humans*
Infant
Korea
Medical Records
Pharynx
Pneumonia
Respiratory System
Respiratory Tract Diseases
Retrospective Studies
DNA