Yonsei Med J.  1973 Dec;14(1):1-9.

Effects of Some Local Anesthetics on Ca++ Binding to Lipid-Extracted RBC Membrane, Egg Albumin Film and Filter Paper

• Kim JS
• Hah JS
• Kang DH

Abstract

Local anesthetics at a concentration of 10 mM(procaine and lidocaine) were found to inhibit competitively Ca++ binding to lipidextracted RBC membrane, and also to egg albumin film fixed on cover glasses or impregnated into Whatman filter paper (No. 1). A competitive inhibition by local anesthetics was also found in Ca++ binding to Whatman filter paper which had been pretreated with organic solvents to extract possible contaminated lipids. Therefore, it is suggested that the local anesthetics inhibit Ca++ binding not only to phospholipids but to some macromolecules such as membrane proteins, egg albumin film and filter paper.

MeSH Terms

Anesthetics, Local/pharmacology*
Calcium/metabolism*
Cell Membrane Permeability/drug effects
Erythrocytes/cytology*
Filtration
Human
Lidocaine/pharmacology
Ovalbumin/metabolism*
Procaine/pharmacology