Ann Lab Med.  2019 Jul;39(4):403-405. 10.3343/alm.2019.39.4.403.

A Rare Case of Acute Myeloid Leukemia With SET-NUP214 Fusion and Massive Hyperdiploidy

• Jeong IH
• An GD
• Lim HH
• Woo KS
• Kim KH
• Kim JM
• Lee JH
• Han JY

• KMID: 2438889
• DOI: http://doi.org/10.3343/alm.2019.39.4.403

Abstract

No abstract available.

MeSH Terms

Leukemia, Myeloid, Acute*

Figure

• 

  Fig. 1 Features of bone marrow aspirate smear and results of chromosomal analysis, FISH, and Sanger sequencing. (A) Bone marrow aspirate smear showing leukemic blasts comprising mostly myeloblasts (Wright-Giemsa stain, ×1,000). (B) Chromosomal analysis showing 59–90,XXYY,−1,−2,−5,−7,−7,−10,−13,−13,−16,−17,−18,−21[cp23]. (C) FISH analysis with a SET/NUP214 probe showing two yellow fusions, and two green and two red probes, suggesting either del(9)(q34.11q34.13) or t(9;9)(q34;q34). (D) FISH analysis with ABL1 probe showing two red (ABL1) and four green (BCR) signals. (E) Sanger sequence analysis of SET and NUP241.

Reference

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