J Periodontal Implant Sci.  2012 Dec;42(6):196-203.

Subepithelial connective tissue graft with and without the use of plasma rich in growth factors for treating root exposure

• Lafzi A
• Faramarzi
• Shirmohammadi A
• Behrozian
• Kashefimehr A
• Khashabi E

Abstract

PURPOSE
The aim of this study was to evaluate the clinical efficiency of the subepithelial connective tissue graft (SCTG) with and without plasma rich in growth factor (PRGF) in the treatment of gingival recessions.
METHODS
Twenty bilateral buccal gingival Miller's Class I and II recessions were selected. Ten of the recessions were treated with SCTG and PRGF (test group). The rest ten of the recessions were treated with SCTG (control group). The clinical parameters including recession depth (RD), percentage of root coverage (RC), mucogingival junction (MGJ) position, clinical attachment level (CAL), and probing depth (PD) were measured at the baseline, and 1 and 3 months later. The data were analyzed using the Wilcoxon signed rank and Mann-Whitney U tests.
RESULTS
After 3 months, both groups showed a significant improvement in all of the mentioned criteria except PD. Although the amount of improvement was better in the SCTG+PRGF group than the SCTG only group, this difference was not statistically significant. The mean RC was 70.85+/-12.57 in the test group and 75.83+/-24.68 in the control group.
CONCLUSIONS
Both SCTG+PRGF and SCTG only result in favorable clinical outcomes, but the added benefit of PRGF is not evident.

Keyword

Connective tissue; Growth factors; Plasma

MeSH Terms

Connective Tissue
Intercellular Signaling Peptides and Proteins
Plasma
Transplants
Intercellular Signaling Peptides and Proteins

Figure

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  Figure 1 Flowchart for the study patients. SCTG: subepithelial connective tissue graft, PRGF: plasma rich in growth factors.

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  Figure 2 Stages of the plasma rich growth factors (PRGF) preparation. (A, B) The withdrawal of the patient's peripheral blood. (C) The centrifuged product. (D) The collected PRGF from the two sample tubes combined into one tube. (E) The addition of calcium chloride for clotting. (F) The PRGF gel.

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  Figure 3 Three layers of plasma rich in growth factors (PRGF). PPGF: Plasma poor in growth factor, PGF: Plasma with growth factor.

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  Figure 4 Treatment of a gingival recession with a subepithelial connective tissue graft and plasma rich in growth factors (PRGF). (A) The baseline clinical situation of the recession defect. (B) Incisions. (C) The application of PRGF gel. (D) The placement of a connective tissue graft. (E) The three-month follow-up appointment.

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