Osteoporos Sarcopenia.  2018 Mar;4(1):29-32. 10.1016/j.afos.2018.02.001.

Utility of radius bone densitometry for the treatment of osteoporosis with once-weekly teriparatide therapy

Affiliations
  • 1Medical Corporation Mishokai Harumi Clinic, Yashio, Japan. oceanhami@hotmail.com
  • 2Hitachi, Ltd., Tokyo, Japan.
  • 3Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Japan.

Abstract


OBJECTIVES
As clinics that treat patients with osteoporosis do not usually have central dual-energy X-ray absorptiometry (DXA), bone density is often measured with radial DXA. However, no long-term evidence exists for radius bone density outcomes following treatment with once-weekly teriparatide in actual medical treatment.
METHODS
We evaluated changes in bone density at 6-, 12-, and 18-month intervals using radial DXA in patients treated with once-weekly teriparatide for more than 6 months.
RESULTS
A significant increase in bone mineral density (BMD) was observed at the 1/3 and 1/10 radius sites 12 months after the initiation of once-weekly teriparatide. We also observed that the rate of change in BMD was greater at the distal 1/10 radius than at the 1/3 radius.
CONCLUSIONS
Considering these points, the effect of once-weekly teriparatide therapy can be observed at the radius. In clinics that do not have central DXA, but instead have radial DXA, these findings can help to evaluate the effect of once-weekly teriparatide treatment on osteoporosis.

Keyword

Once-weekly teriparatide; Osteoporosis; Radius; Dual-energy X-ray absorptiometry
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