J Korean Neurol Assoc.
2018 Nov;36(4):329-332. 10.17340/jkna.2018.4.11.
Rituximab Treatment for Polyneuropathy Induced by an Immune Checkpoint Inhibitor
- Affiliations
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- 1Department of Neurology, Seoul National University Hospital, Seoul, Korea.. staelee@gmail.com
- 2Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
- KMID: 2435845
- DOI: http://doi.org/10.17340/jkna.2018.4.11
Abstract
- Immune checkpoint inhibitor is associated with variety of immune-related adverse events. We present a case of polyneuropathy induced by immune checkpoint inhibitor, which was refractory to steroid and immunoglobulin. While high-dose steroid and immunoglobulin were not effective, we tried rituximab which is effective in other immune-mediated polyneuropathy. After rituximab treatment, patient's clinical symptom and nerve conduction study finding was markedly improved. We suggest rituximab might be effective in polyneuropathy induced by immune checkpoint inhibitor.
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