J Korean Neurol Assoc.
2018 Feb;36(1):19-21. 10.17340/jkna.2018.1.4.
Steroid Non-responsive Hashimoto's Encephalopathy Improved by Rituximab
- Affiliations
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- 1Department of Neurology, Keimyung University School of Medicine, Daegu, Korea.
- 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. moonhyejin21@gmail.com
- KMID: 2435779
- DOI: http://doi.org/10.17340/jkna.2018.1.4
Abstract
- Hashimoto's encephalopathy is a rare autoimmune disease, with symptoms of encephalopathy and high titers of serum anti-thyroid antibodies. Current diagnostic criteria include corticosteroid responsiveness, but in some cases, they are refractory to corticosteroids. In steroid non-responders, other immunomodulatory therapies could be applied. Recently, Rituximab is reported as a safe and effective treatment for Hashimoto's encephalopathy. We report a 50-year-old woman with Hashimoto's encephalopathy presented with confusion and catatonia who was refractory to corticosteroid and immunoglobulin but effectively treated with rituximab.
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