J Korean Soc Emerg Med.  2018 Aug;29(4):304-311. 10.0000/jksem.2018.29.4.304.

Clinical characteristics and mortality-predictive factors analyses of glyphosate intoxication

• Son CH
• Lee SH
• Jang TC
• Kim GM
• Ko SH
• Seo YW

• KMID: 2435482
• DOI: http://doi.org/10.0000/jksem.2018.29.4.304

Abstract

OBJECTIVE
Glyphosate intoxicated patients are increasing as glyphosate use increases. This study was conducted to analyze clinical characteristics of glyphosate intoxication patients to provide early treatment to high risk patients.
METHODS
We retrospectively collected data pertaining to glyphosate intoxicated patients who visited emergency department from January 2012 to December 2016 based on medical records. The patients were divided into survivors and deaths, after which their clinical characteristics and laboratory results were compared.
RESULTS
Among 84 glyphosate intoxicated patients, 12 died (14.3%). The mortality group showed advanced age (P=0.006), low blood pressure (P=0.001), worse mental status (P=0.000), low arterial blood pH (P=0.000), high serum creatinine (P=0.030), high glucose (P=0.000), high serum lactate (P=0.011), and low serum albumin (P=0.034). Logistic multivariate regression analysis revealed that the mortality group had advanced age (odds ratio [OR], 1.193), high serum glucose (OR, 1.018), and low systolic blood pressure (OR, 0.961) compared to the survivor group.
CONCLUSION
On the scene and emergency department, glyphosate intoxicated patients with advanced age, high serum glucose level, and low systolic blood pressure should be provided early supportive treatments and transported to a toxicology facility.

Keyword

Clinical characteristics; Glyphosate; Intoxication; Mortality

MeSH Terms

Blood Glucose
Blood Pressure
Creatinine
Emergency Service, Hospital
Glucose
Humans
Hydrogen-Ion Concentration
Hypotension
Lactic Acid
Medical Records
Mortality
Retrospective Studies
Serum Albumin
Survivors
Toxicology
Creatinine
Glucose
Lactic Acid
Serum Albumin