Child Kidney Dis.
2018 Apr;22(1):17-21. 10.3339/jkspn.2018.22.1.17.
The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis
- Affiliations
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- 1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. shinji@yuhs.ac
- 2Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Korea.
- 3Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 4Konyang University College of Medicine, Daejeon, Korea.
- 5Chonbuk National University College of Medicine, Jeonju, Korea.
- 6Chonnam National University College of Medicine, Gwangju, Korea.
- 7Luton&Dunstable University Hospital NHS Foundation Trust, Luton, United Kingdom.
- 8Yonsei University College of Medicine, Seoul, Korea.
- 9University of Hamburg, Medical Faculty, Hamburg, Germany.
- 10Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 2435350
- DOI: http://doi.org/10.3339/jkspn.2018.22.1.17
Abstract
- Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.
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