Korean J Med.  2018 Jun;93(3):300-305. 10.3904/kjm.2018.93.3.300.

A Case of Synchronous Lung Squamous Cell Carcinoma and Diffuse Large B-cell Lymphoma

• Lee SJ
• Lim SY
• Yoo TK
• Kim SK
• Kim YG
• Lee HJ
• Song JU

• KMID: 2435170
• DOI: http://doi.org/10.3904/kjm.2018.93.3.300

Abstract

A 65-year-old male was referred to our hospital for evaluation of a right pleural effusion. Thoracic computed tomography (CT) revealed a huge central mass with right hilar and subcarinal lymph node conglomerates. An endobronchial mass was incidentally found in the right upper lobe bronchus, and endobronchial ultrasound-guided transbronchial needle biopsy of the mediastinal lymph nodes was thus also performed at the time of bronchoscopy. The two biopsies revealed squamous cell carcinoma and diffuse large B-cell lymphoma (DLBCL), respectively. As the pathology of the mediastinal lymph nodes was unknown, the lung cancer could not be accurately staged. Thus, we treated the DLBCL; follow-up positron emission tomography/CT after two cycles of chemotherapy showed that the conglomerate mass had disappeared but the right upper lobe lesion remained. Lung cancer staging thus became more accurate and radical treatment could be considered. To the best of our knowledge, this is the first report of a co-existing squamous cell carcinoma of the lung and DLBCL of the intrapulmonary lymph nodes.

Keyword

Multiple primary cancer; Lymphoma; Mediastinum; Lung cancer; Squamous cell carcinoma

MeSH Terms

Aged
B-Lymphocytes*
Biopsy
Biopsy, Needle
Bronchi
Bronchoscopy
Carcinoma, Squamous Cell*
Drug Therapy
Electrons
Epithelial Cells*
Follow-Up Studies
Humans
Lung Neoplasms
Lung*
Lymph Nodes
Lymphoma
Lymphoma, B-Cell*
Male
Mediastinum
Pathology
Pleural Effusion