Yeungnam Univ J Med.  2018 Dec;35(2):187-191. 10.12701/yujm.2018.35.2.187.

Risk factors for respiratory distress syndrome in full-term neonates

• Kim JH
• Lee SM
• Lee YH

• KMID: 2433737
• DOI: http://doi.org/10.12701/yujm.2018.35.2.187

Abstract

BACKGROUND
Respiratory distress syndrome (RDS) is a one of the most common cause of respiratory morbidity and mortality in neonates. This study was conducted to investigate the risk factors for RDS in full-term neonates.
METHODS
We conducted this retrospective study using medical records. The study group included 80 full-term neonates diagnosed with RDS and hospitalized in the neonatal intensive care unit between January 2012 and December 2016, at Yeungnam University Hospital. We analyzed sex, gestational age, birth weight, delivery method, maternal age, number of pregnancy, history of abortion, and complication of pregnancy. The control group included 116 full-time neonates who were hospitalized with jaundice during the same period.
RESULTS
The incidence of full-term RDS was more common in males (odds ratio [OR], 3.288; 95% confidence interval [CI], 1.446-7.479), cesarean section (OR, 15.03; 95% CI, 6.381-35.423), multiparity (OR, 4.216; 95% CI, 1.568-11.335). The other factors rendered no significant results.
CONCLUSION
The risk factors for RDS in full-tern neonates were identified as male sex, cesarean section, and multiparity. Further studies involving more institutions are needed to clarify the risk factors for RDS in fullterm infants.

Keyword

Full-term; Neonatal respiratory distress syndrome; Risk factor

MeSH Terms

Birth Weight
Cesarean Section
Female
Gestational Age
Humans
Incidence
Infant
Infant, Newborn*
Intensive Care, Neonatal
Jaundice
Male
Maternal Age
Medical Records
Methods
Mortality
Parity
Pregnancy
Respiratory Distress Syndrome, Newborn
Retrospective Studies
Risk Factors*

Reference

1. Koivisto M, Marttila R, Kurkinen-Räty M, Saarela T, Pokela ML, Jouppila P, et al. Changing incidence and outcome of infants with respiratory distress syndrome in the 1990s: a population-based survey. Acta Paediatr. 2004; 93:177–84.

2. Perelman RH, Palta M, Kirby R, Farrell PM. Discordance between male and female deaths due to the respiratory distress syndrome. Pediatrics. 1986; 78:238–44.

3. Hibbard JU, Wilkins I, Sun L, Gregory K, Haberman S, Hoffman M, et al. Respiratory morbidity in late preterm births. JAMA. 2010; 304:419–25.

4. Condò V, Cipriani S, Colnaghi M, Bellù R, Zanini R, Bulfoni C, et al. Neonatal respiratory distress syndrome: are risk factors the same in preterm and term infants? J Matern Fetal Neonatal Med. 2017; 30:1267–72.

5. Agrawal V, David RJ, Harris VJ. Classification of acute respiratory disorders of all newborns in a tertiary care center. J Natl Med Assoc. 2003; 95:585–95.

6. Edwards MO, Kotecha SJ, Kotecha S. Respiratory distress of the term newborn infant. Paediatr Respir Rev. 2013; 14:29–36.

7. Lee JM, Kim DK, Lee SJ. Probable prognostic factors among the revealing clinical manifestations at admission in neonates with tachypnea. J Korean Soc Neonatol. 2006; 13:32–9. Korean.

8. Liu J, Shi Y, Dong JY, Zheng T, Li JY, Lu LL, et al. Clinical characteristics, diagnosis and management of respiratory distress syndrome in full-term neonates. Chin Med J (Engl). 2010; 123:2640–4.

9. Dani C, Reali MF, Bertini G, Wiechmann L, Spagnolo A, Tangucci M, et al. Risk factors for the development of respiratory distress syndrome and transient tachypnoea in newborn infants. Eur Respir J. 1999; 14:155–9.

10. Bresson E, Seaborn T, Côté M, Cormier G, Provost PR, Piedboeuf B, et al. Gene expression profile of androgen modulated genes in the murine fetal developing lung. Reprod Biol Endocrinol. 2010; 8:2.

11. Nielsen HC, Torday JS. Sex differences in avian embryo pulmonary surfactant production: evidence for sex chromosome involvement. Endocrinology. 1985; 117:31–7.

12. Seaborn T, Simard M, Provost PR, Piedboeuf B, Tremblay Y. Sex hormone metabolism in lung development and maturation. Trends Endocrinol Metab. 2010; 21:729–38.

13. Nielsen HC. Androgen receptors influence the production of pulmonary surfactant in the testicular feminization mouse fetus. J Clin Invest. 1985; 76:177–81.

14. Hansen AK, Wisborg K, Uldbjerg N, Henriksen TB. Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study. BMJ. 2008; 336:85–7.

15. Roth-Kleiner M, Wagner BP, Bachmann D, Pfenninger J. Respiratory distress syndrome in near-term babies after caesarean section. Swiss Med Wkly. 2003; 133:283–8.

16. Melamed N, Klinger G, Tenenbaum-Gavish K, Herscovici T, Linder N, Hod M, et al. Short-term neonatal outcome in low-risk, spontaneous, singleton, late preterm deliveries. Obstet Gynecol. 2009; 114:253–60.

17. Altman M, Vanpée M, Cnattingius S, Norman M. Risk factors for acute respiratory morbidity in moderately preterm infants. Paediatr Perinat Epidemiol. 2013; 27:172–81.

18. Liu J, Yang N, Liu Y. High-risk factors of respiratory distress syndrome in term neonates: a retrospective case-control study. Balkan Med J. 2014; 31:64–8.

19. Wiswell TE, Tuggle JM, Turner BS. Meconium aspiration syndrome: have we made a difference? Pediatrics. 1990; 85:715–21.