J Korean Pediatr Soc.  1996 Mar;39(3):319-325.

Plasma Fibronectin Concentration in the Neonate

• Yoo Y
• Lee KC
• Tockgo YC

Abstract

PURPOSE
Plasma fibronectin is thought to have important role in the inflammatory response and host defense. We performed this study to evaluate concentration in the full-term, healthy preterm, asphyxia and respiratory distress syndrome and how that correlated with gestational age and birth weight.
METHODS
We evaluate 51 neonates who were delivered at Korea University Hospital from Jan. 1992 to Jul. 1992. In order to evaluate concentration of plasma fibronectin according to gestational age and birth weight in 51 neonates, we measured plasma fibronectin in healthy premature and term infants and investigated the alteration in plasma values in infants with perinatal asphyxia and respiratory distress syndrome.
RESULTS
1) The concentration of plasma fibronectin was lower in preterm infants(123+/-30ug/dl) than in term infants(151+/-26ug/dl). 2) There was a significant correlation between the plasma fibronectin concentration and both gestational age and weight (p<0.01). 3) The infant with perinatal asphyxia and respiratory distress syndrome had lower plasma fibronectin concentration than those in age matched healthy infant.
CONCLUSIONS
This results shows that the plasma fibronectin correlate with gestational age and birth weight and suggests that deficiency of plasma fibronectin correlate with reticuloendothelial system hypofunction in infants with complicated birth.

Keyword

Fibronectin; Neonate

MeSH Terms

Asphyxia
Birth Weight
Fibronectins*
Gestational Age
Humans
Infant
Infant, Newborn*
Korea
Mononuclear Phagocyte System
Parturition
Plasma*
Fibronectins