J Neurogastroenterol Motil.  2017 Apr;23(2):180-196. 10.5056/jnm16194.

Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity

• Prinz P
• Stengel A

• KMID: 2433519
• DOI: http://doi.org/10.5056/jnm16194

Abstract

This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative"”physical activity and pharmacotherapy"”treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways.

Keyword

Bariatric surgery; Brain-gut axis; Deep brain stimulation; Psychosomatic; Obesity

MeSH Terms

Appetite
Bariatric Surgery
Cholecystokinin
Deep Brain Stimulation
Eating*
Gastrointestinal Tract
Ghrelin
Glucagon-Like Peptide 1
Obesity*
Peptide YY
Peptides*
Cholecystokinin
Ghrelin
Glucagon-Like Peptide 1
Peptide YY
Peptides