Ultrasonography.  2019 Jan;38(1):58-66. 10.14366/usg.17067.

Acoustic radiation force impulse imaging of biopsy-proven Kikuchi disease: initial experiences for evaluating feasibility in pediatric patients

• Lee JM
• Hwang JY
• Bae J
• Kim MR
• Kim YW
• Park SE
• Yeom JA
• Roh J

• KMID: 2433293
• DOI: http://doi.org/10.14366/usg.17067

Abstract

PURPOSE
This study evaluated the feasibility of acoustic radiation force impulse (ARFI) elastography and characterized the sonographic features of lymph nodes (LNs) with Kikuchi disease in pediatric patients.
METHODS
Seventy-six cervical LN biopsies were performed for the diagnosis of cervical lymphadenopathy. ARFI imaging was performed, and the characteristic ultrasound features of the biopsied LNs and the contralateral LNs were analyzed. We also reviewed clinical and conventional ultrasonographic findings.
RESULTS
On histology, 56 patients were diagnosed with Kikuchi disease. These LNs were large and elongated, with increased perinodal echogenicity and capsular thickening. In 38 of them, ARFI elastography was performed, and the median shear wave velocity (SWV) of the biopsied LNs with Kikuchi disease (2.19 m/sec; range, 1.45 to 4.57 m/sec) was higher than of the contralateral LNs (1.72 m/sec; range, 0.95 to 2.65 m/sec; P < 0.001). In patients with reactive hyperplasia, the mean SWV of the biopsied LNs (2.00 m/sec; range, 1.49 to 2.26 m/sec) was higher than that of the contralateral LNs (1.55 m/sec; range, 1.21 to 2.32 m/sec; P=0.031).
CONCLUSION
The SWV of LNs with Kikuchi disease was significantly higher than that of the contralateral LNs. Morphologically, LNs with Kikuchi disease showed an enlarged, elongated, and oval shape, increased perinodal echogenicity, and capsular thickening. In addition to the conventional ultrasonographic findings, the application of ARFI is feasible even in pediatric patients for the evaluation of cervical lymphadenopathy.

Keyword

Elasticity imaging techniques; Histiocytic necrotizing lymphadenitis; Ultrasonography; Pediatrics

MeSH Terms

Acoustics*
Biopsy
Diagnosis
Elasticity Imaging Techniques*
Histiocytic Necrotizing Lymphadenitis*
Humans
Hyperplasia
Lymph Nodes
Lymphatic Diseases
Pediatrics
Ultrasonography