Allergy Asthma Immunol Res.  2019 Mar;11(2):222-230. 10.4168/aair.2019.11.2.222.

Multicenter Adherence Study of Asthma Medication for Children in Korea

  • 1Asthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
  • 2School of Biological Sciences, College of Natural Science, University of Ulsan, Ulsan, Korea.
  • 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 4Department of Pediatrics, School of Medicine, Kyung Hee University, Seoul, Korea.
  • 5Department of Pediatrics, Childhood Asthma and Atopy Center, Asan Medical Center, Seoul, Korea.
  • 6Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.
  • 7Department of Pediatrics, The Catholic University of Korea Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
  • 8Department of Pediatrics, Inha University Hospital, Incheon, Korea.
  • 9Department of Pediatrics, Busan St. Mary Hospital, Busan, Korea.
  • 10Department of Pediatrics, Presbyterian Medical Center, Jeonju, Korea.
  • 11Rose Mary's Hospital, Daegu, Korea.
  • 12Department of Pediatrics, Daegu Catholic University Medical Center, Catholic University of Daegu, Daegu, Korea.
  • 13Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea.
  • 14Department of Pediatrics, Good Kang-An Hospital, Busan Korea.
  • 15Department of Pediatrics, FATIMA Hospital, Daegu, Korea.
  • 16Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.
  • 17Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Korea.
  • 18Department of Pediatrics, Dong-A University College of Medicine, Pusan, Korea.
  • 19Department of Pediatrics, I Dream Place Children's Hospital, Daegu, Korea.
  • 20Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 21Department of Pediatrics, The Catholic University of Korea Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
  • 22Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.


Adherence is a major component of successful medical treatment. However, non-adherence remains a barrier to effective delivery of healthcare worldwide.
Twenty healthcare facilities (secondary or tertiary hospitals) belonging to the Korean Academy of Pediatric Allergy and Respiratory Diseases (KAPARD) participated. Questionnaires were given to patients currently receiving treatment in the form of inhalant useor oral intake or transdermal patch for mild to moderate asthma.
A total of 1,838 patients responded to the questionnaire. Mean age was 5.98 ± 3.79 years (range: 0-18 years). With help from their caregivers, the percentage of patients that answered "taking as prescribed" was 38.04% for inhalant users, 50.09% for oral medication users and 67.42% for transdermal users. Transdermal patch users had significantly greater adherence compared to the other 2 groups (P < 0.001). The 34.15% of inhalant users, 70.33% of oral medication users and 93.00% of transdermal patch users felt that their medication delivery system was "Easy" or "Very easy" to use (P < 0.001). "Method of administration" was deemed to be the most difficult part of the treatment regimen to follow, and 76.7% of patients preferred once-daily administration (i.e., "Frequency of administration").
Asthma medication adherence in young children was found to be better in the transdermal patch group. This may be due to requiring fewer doses and easy to follow instructions. From an adherence point of view, the transdermal patch seems more useful for long-term asthma control in children compared to oral or inhaled medicine.


Adherence; asthma; medication

MeSH Terms

Delivery of Health Care
Medication Adherence
Transdermal Patch
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