Asian Oncol Nurs.  2013 Dec;13(4):201-209. 10.5388/aon.2013.13.4.201.

Factors Influencing Medication Adherence to Oral Anticancer Drugs

Affiliations
  • 1College of Nursing, Pusan National University, Yangsan, Korea. vandi@pusan.ac.kr

Abstract

PURPOSE
The purpose of this study was to identify factors that influence on medication adherence to oral anticancer drugs.
METHODS
147 cancer patients receiving oral anticancer drugs were surveyed. The survey content included medication adherence, social support, depression, self-efficacy and symptom experience.
RESULTS
The mean medication adherence was 6.77 based on 8 points (84.6 based on 100 points). The influencing factors on medication adherence were symptom experience (beta=-.19), decision of oral chemotherapy (beta=.25) and social support (beta=.21), and 17.0% of the variance in medication adherence was explained by these three factors in stepwise multiple regression analysis.
CONCLUSION
The level of medication adherence to oral anticancer drugs was relatively high, and increased by decreasing symptom experience, and increasing social support. Considering the medication adherence is related with positive treatment outcome, nursing effort to improve medication adherence by decreasing symptom experience, and increasing social support is needed.

Keyword

Mouth; Drug Therapy; Medication Adherence; Neoplasms

MeSH Terms

Depression
Drug Therapy
Humans
Medication Adherence*
Mouth
Nursing
Treatment Outcome

Cited by  2 articles

Effects of a Medication Management Program for Cancer Patients Receiving Oral Chemotherapy
Han Sooyoung, Kim Sue, Lee Yoonjung
Asian Oncol Nurs. 2018;18(2):94-103.    doi: 10.5388/aon.2018.18.2.94.

Predictors Influencing of Medication Adherence in Hemodialysis Patients
Hana Kim, Eunha Kim
Korean J Adult Nurs. 2019;31(3):283-292.    doi: 10.7475/kjan.2019.31.3.283.


Reference

1. Banna GL, Collovà E, Gebbia V, Lipari H, Giuffrida P, Cavallaro S, et al. Anticancer oral therapy: Emerging related issues. Cancer Treat Rev. 2010; 36(8):595–605.
Article
2. Regnier Denois V, Poirson J, Nourissat A, Jacquin JP, Guastalla JP, Chauvin F. Adherence with oral chemotherapy: results from a qualitative study of the behaviour and representations of patients and oncologists. Eur J Cancer Care (Engl). 2011; 20(4):520–527.
Article
3. Benjamin L, Cotté FE, Philippe C, Mercier F, Bachelot T, Vidal-Trécan G. Physicians' preferences for prescribing oral and intravenous anticancer drugs: a Discrete Choice Experiment. Eur J Cancer. 2012; 48(6):912–920.
Article
4. Hartigan K. Patient education: the cornerstone of successful oral chemotherapy treatment. Clin J Oncol Nurs. 2003; 7:6 Suppl. 21–24.
Article
5. Moore S. Facilitating oral chemotherapy treatment and compliance through patient/family-focused education. Cancer Nurs. 2007; 30(2):112–122.
Article
6. Foulon V, Schoffski P, Wolter P. Patient adherence to oral anticancer drugs: an emerging issue in modern oncology. Acta Clin Belg. 2011; 66(2):85–96.
7. World Health Organization. Adherence to long-term therapies: evidence for actions. Geneva: WHO;Accessed April 15, 2013. Available from: http://www.who.int/chp/knowlege/publications/adherence_report/en/print.html.
8. Ruddy K, Mayer E, Partridge A. Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin. 2009; 59(1):56–66.
Article
9. Verbrugghe M, Verhaeghe S, Lauwaert K, Beeckman D, Van Hecke A. Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review. Cancer Treat Rev. 2013; 39(6):610–621.
Article
10. Gater A, Heron L, Abetz-Webb L, Cooms J, Simmons J, Guilhot F, et al. Adherence to oral tyrosine kinase inhibitor therapies in chronic myeloid leukemia. Leuk Res. 2012; 36:817–825.
Article
11. Marques PAC, Pierin AMG. Factors that affect cancer patient compliance to oral anti-neoplastic therapy. Acta Paul Enferm. 2008; 21(2):323–329.
Article
12. Banning M. Adherence to adjuvant therapy in post-menopausal breast cancer patients: a review. Eur J Cancer Care (Engl). 2012; 21(1):10–19.
Article
13. Jabbour EJ, Kantarjian H, Eliasson L, Megan Cornelison A, Marin D. Patient adherence to tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Am J Hematol. 2012; 87(7):687–691.
Article
14. Partridge AH, Avorn J, Wang PS, Winer EP. Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst. 2002; 94(9):652–661.
Article
15. Choi JS. Adherence to oral anticancer drugs in elderly cancer patients [dissertation]. Seoul: Seoul National Univ.;2011.
16. Lee ER. Patient compliance with oral anticancer drug medication and factors affecting compliance with medication [dissertation]. Seoul: Seoul National Univ.;2006.
17. Kim JH. Influencing factors on medication adherence in colorectal cancer patient receiving oral chemotherapy. Asian Oncol Nurs. 2012; 12(3):213–220.
Article
18. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. New York: Academic Press;1977.
19. Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, et al. Assessing symptom distress in cancer patients: the M. D. Anderson Symptom Inventory. Cancer. 2000; 89(7):1634–1646.
20. Yun YH, Mendoza TR, Kang IO, You CH, Roh JW, Lee CG, et al. Validation study of the Korean version of the M. D. Anderson Symptom Inventory. J Pain Symptom Manage. 2006; 31(4):345–352.
Article
21. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977; 1(3):385–401.
22. Cho MJ, Kim KH. Diagnostic validity of the CES-D (Korean Version) in the assessment of DSM-III-R Major Depression. J Korean Neuropsychiatr Assoc. 1993; 32(3):381–399.
23. Heitzmann CA, Merluzzi TV, Jean-Pierre P, Roscoe JA, Kirsh KL, Passik SD. Assessing self-efficacy for coping with cancer: development and psychometric analysis of the brief version of the Cancer Behavior Inventory (CBI-B). Psychooncology. 2011; 20(3):302–312.
Article
24. Zimet GD, Dahlem NW, Zimet SG, Farley GK. The multidimensional scale of perceived social support. J Pers Assess. 1988; 52(1):30–41.
Article
25. Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008; 10(5):348–354.
Article
26. Grunfeld EA, Hunter MS, Sikka P, Mittal S. Adherence beliefs among breast cancer patients taking tamoxifen. Patient Educ Couns. 2005; 59(1):97–102.
Article
27. Kirk MC, Hudis CA. Insight into barriers against optimal adherence to oral hormonal therapy in women with breast cancer. Clin Breast Cancer. 2008; 8(2):155–161.
Article
28. Lien CY, Lin HR, Kuo IT, Chen ML. Perceived uncertainty, social support and psychological adjustment in older patients with cancer being treated with surgery. J Clin Nurs. 2009; 18(16):2311–2319.
Article
29. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment. Arch Intern Med. 2000; 160(14):2101–2107.
Article
30. Darkow T, Henk HJ, Thomas SK, Weiwei F, Baladi JF, Goldberg GA, et al. Treatment interruptions and non-adherence with imatinib and associated healthcare costs: a retrospective analysis among managed care patients with chronic myelogenous leukaemia. Pharmacoeconomics. 2007; 25(6):481–496.
Article
Full Text Links
  • AON
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr