Anxiety Mood.  2018 Oct;14(2):53-62. 10.24986/anxmod.2018.14.2.53.

Korean Guidelines for the Treatment of Panic Disorder 2018 : Initial and Maintenance Treatment Strategies for the Pharmacological Treatment of Panic Disorder

Affiliations
  • 1Department of Psychiatry, CHA University School of Medicine, Seoul, Korea. freud@chol.com
  • 2Department of Psychiatry, National Rehabilitation Center, Seoul, Korea.
  • 3Department of Psychiatry, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 4Department of Psychiatry, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 5Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.
  • 6Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
  • 7Department of Psychiatry, College of Medicine, Yeungnam University, Daegu, Korea.
  • 8Department of Psychiatry, Chonbuk National University Hospital, Jeonju, Korea.
  • 9Department of Psychiatry, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
  • 10Dr. Yu's Psychiatric Clinic, Seoul, Korea.

Abstract


OBJECTIVE
The Korean Association of Anxiety Disorders developed Korean guidelines for treatment of panic disorder (PD) 2018. In this paper, we discussed the consensus among psychiatrists, regarding initial and maintenance treatment strategies for pharmacological treatment of PD in Korea.
METHODS
Based on current treatment guidelines published by the American Psychiatric Association, the National Institute for Clinical Excellence, and the Canadian Psychiatric Association, we developed questionnaires pertinent to initial and maintenance treatment strategies for pharmacological treatment of PD. Seventy-two experts in PD answered questionnaires. We classified expert opinions into three categories, first, second, and third-line treatment strategies, by analyzing the 95% confidence interval.
RESULTS
Antidepressants, benzodiazepine anxiolytics, and cognitive-behavioral therapy (CBT) were recommended as treatments of choice (ToC), and first-line strategies for initial treatment of PD. Escitalopram, paroxetine, sertraline, and venlafaxine were preferred from among many anti-panic drugs. Mean starting dose of anti-panic drugs for initial treatment of PD was relatively lower, than that for other psychiatric illnesses such as major depressive disorder. In the case of maintenance treatment of PD, antidepressants and CBT were selected as ToC and first-line strategies. Patients were typically examined every four weeks during treatment, to review effectiveness and side effects of the drug. Pharmacotherapy was generally continued for one year or more.
CONCLUSION
This study provides information about consensus among Korean experts regarding pharmacological treatment strategies for patients with panic disorder.

Keyword

Panic disorder; Treatment guidelines; Pharmacological treatment; Initial treatment; Maintenance treatment

MeSH Terms

Anti-Anxiety Agents
Antidepressive Agents
Anxiety Disorders
Benzodiazepines
Citalopram
Consensus
Depressive Disorder, Major
Drug Therapy
Expert Testimony
Humans
Korea
Panic Disorder*
Panic*
Paroxetine
Psychiatry
Sertraline
Venlafaxine Hydrochloride
Anti-Anxiety Agents
Antidepressive Agents
Benzodiazepines
Citalopram
Paroxetine
Sertraline
Venlafaxine Hydrochloride
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