J Korean Med Sci.  2018 Dec;33(52):e331. 10.3346/jkms.2018.33.e331.

Current Status of Human Papillomavirus Infection and Introduction of Vaccination to the National Immunization Program in Korea: an Overview

• Kim MA
• Han GH
• Kim JH
• Seo K

• KMID: 2429595
• DOI: http://doi.org/10.3346/jkms.2018.33.e331

Abstract

Human Papillomavirus (HPV) infection is the most common sexually transmitted infection and is associated with the development of cervical cancer. The purpose of this report is to provide the literature evidences on selecting the HPV vaccine for national immunization program (NIP) in Korea. To complete these tasks, we reviewed domestic and foreign literature on the current status of HPV infection, efficacy and effectiveness of HPV vaccine, safety of vaccine and cost effectiveness analysis of vaccination business. Given that the median age of first sexual intercourse is continuing to fall, this may have serious implications for HPV infection and cervical cancer incidence at the age of 20s. The World Health Organization recommends that the HPV vaccination should be included in the NIP being implemented in each country. Both the bivalent and quadrivalent vaccines have a 90% or greater preventive efficacy on cervical intraepithelial lesion 2-3 and cervical cancer by the HPV 16 or HPV 18. In the future, if HPV vaccination rate as part of NIP increases, it is expected that the incidence of HPV infection, genital warts, and cervical precancerous lesions will be decreased in the vaccination age group. Therefore, in order to increase the HPV vaccination rate at this point in Korea, social consensus and efforts such as the introduction and promotion of HPV vaccine to the NIP according to appropriate cost-effectiveness analysis are required.

Keyword

Human Papillomavirus Infection; National Immunization Program; Vaccination; Cervical Cancer

MeSH Terms

Coitus
Commerce
Condylomata Acuminata
Consensus
Cost-Benefit Analysis
Human papillomavirus 16
Human papillomavirus 18
Humans*
Immunization Programs*
Immunization*
Incidence
Korea*
Papillomavirus Infections*
Sexually Transmitted Diseases
Uterine Cervical Neoplasms
Vaccination*
Vaccines
World Health Organization
Vaccines