J Stroke.
2018 May;20(2):208-217. 10.5853/jos.2018.00150.
Intracranial Large Artery Disease of Non-Atherosclerotic Origin: Recent Progress and Clinical Implications
- Affiliations
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- 1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ohyoung.bang@samsung.com
- 2Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
- 3Department of Neurology, University Clinical Hospital of Valladolid, Valladolid, Spain.
- 4Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
- 5Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 2424424
- DOI: http://doi.org/10.5853/jos.2018.00150
Abstract
- Intracranial large artery disease (ILAD) is the major cause of stroke worldwide. With the application of recently introduced diagnostic techniques, the prevalence of non-atherosclerotic ILAD is expected to increase. Herein, we reviewed recent reports and summarized progress in the diagnosis and clinical impact of differentiation between ILAD of atherosclerotic and non-atherosclerotic origin. Our review of the literature suggests that more careful consideration of non-atherosclerotic causes and the application of appropriate diagnostic techniques in patients with ILAD may not only provide better results in the treatment of patients, but it may also lead to more successful clinical trials for the treatment of intracranial atherosclerosis.
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