Immune Netw.  2012 Aug;12(4):129-138.

Immune Disorders and Its Correlation with Gut Microbiome

• Hwang JS
• Im CR
• Im SH

Abstract

Allergic disorders such as atopic dermatitis and asthma are common hyper-immune disorders in industrialized countries. Along with genetic association, environmental factors and gut microbiota have been suggested as major triggering factors for the development of atopic dermatitis. Numerous studies support the association of hygiene hypothesis in allergic immune disorders that a lack of early childhood exposure to diverse microorganism increases susceptibility to allergic diseases. Among the symbiotic microorganisms (e.g. gut flora or probiotics), probiotics confer health benefits through multiple action mechanisms including modification of immune response in gut associated lymphoid tissue (GALT). Although many human clinical trials and mouse studies demonstrated the beneficial effects of probiotics in diverse immune disorders, this effect is strain specific and needs to apply specific probiotics for specific allergic diseases. Herein, we briefly review the diverse functions and regulation mechanisms of probiotics in diverse disorders.

Keyword

Hygiene hypothesis; Intestinal microflora; Gut-Associated lymphoid tissue; Probiotics; Atopic dermatitis

MeSH Terms

Animals
Asthma
Dermatitis, Atopic
Developed Countries
Humans
Hygiene Hypothesis
Immune System Diseases
Insurance Benefits
Lymphoid Tissue
Metagenome
Mice
Probiotics
Sprains and Strains