Korean J Gastroenterol.  2018 Sep;72(3):150-154. 10.4166/kjg.2018.72.3.150.

Primary Hepatic Schwannoma

• Choi YI
• Kim YS
• Kim JH
• Lee SH
• Shin SG
• Kim YS
• Choi DJ
• Choi SJ
• Chung DH
• Kwon OS

• KMID: 2420754
• DOI: http://doi.org/10.4166/kjg.2018.72.3.150

Abstract

A primary benign schwannoma of the liver is extremely rare. Only 30 cases have been reported in the medical literature worldwide, and only one case has been reported in Korea previously. A 56-year-old man was admitted to Gil Medical Center with incidental findings of a hepatic mass by abdominal computed tomography. The computed tomography and magnetic resonance image revealed a 3×2 cm-sized solid mass in the left lobe of the liver. Histological examination confirmed the diagnosis of a benign schwannoma, proven by positive immunoreaction with the neurogenic marker S-100 protein and a negative response to CD34, CD117, and smooth muscle actin. We report a primary benign schwannoma of the liver and review the literature.

Keyword

Neurilemmoma; Peripheral nervous system neoplasms

MeSH Terms

Actins
Diagnosis
Humans
Incidental Findings
Korea
Liver
Middle Aged
Muscle, Smooth
Neurilemmoma*
Peripheral Nervous System Neoplasms
S100 Proteins
Actins
S100 Proteins

Figure

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  Fig. 1. Abdominal ultrasonography (US). US revealed an about 3 cm-sized, low echoic mass with homogeneous pattern in the left lobe of the liver.

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  Fig. 2. Dynamic abdominal computed tomography (CT). (A) Arterial phase (arrow), (B) portal phase (arrow), (C) venous phase: CT showed a well-defined, rounded (arrow), low-attenuating mass with homogeneous attenuation in the left lobe of the liver.

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  Fig. 3. Liver magnetic resonance imaging. (A) T1-WI. A 35 mm suspicious enhancing lesion (white arrow) in the left liver: a mass that is mildly hypointense or isointense on non-contrasted T1-WI. (B) T2-WI. Lesion (white arrow) was heterogeneously hyperintense. (C) Hepatobiliary phase. Gadoxetic-acid enhanced heaptobiliary phase images show hypointense lesion (white arrow). WI, weighted image.

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  Fig. 4. Histologic examination. (A) The sections show a moderately cellular schwannoma. Mitoses are inconspicuous (H&E, ×200). (B) The tumor is composed of bundles of compact spindle cells that are immunoreactive to S-100 protein, brown particles (immunohistochemical stain, ×200).

Reference

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