Knee Surg Relat Res.
2018 Sep;30(3):179-186. 10.5792/ksrr.17.061.
Infrapatellar Fat Pad-Derived Stem Cell-Based Regenerative Strategies in Orthopedic Surgery
- Affiliations
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- 1Department of Biomedical Engineering, Ankara University Faculty of Engineering, Ankara, Turkey.
- 2Ankara University Biotechnology Institute, Ankara, Turkey.
- 3Department of Orthopedics and Traumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey. gazihuri@hacettepe.edu.tr
- KMID: 2420343
- DOI: http://doi.org/10.5792/ksrr.17.061
Abstract
- Infrapatellar fat pad is a densely vascularized and innervated extrasynovial tissue that fills the anterior knee compartment. It plays a role in knee biomechanics as well as constitutes a source of stem cells for regeneration after knee injury. Infrapatellar fat pad-derived stem cells (IPFP-ASCs) possess enhanced and age-independent differentiation capacity as compared to other stem cells, which makes them a very promising candidate in stem cell-based regenerative therapy. The aims of this review are to outline the latest advances and potential trends in using IPFP-ASCs and to emphasize the advantages over other sources of stem cells for applications in orthopedic surgery.
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