Korean J Intern Med.  2018 Sep;33(5):1000-1007. 10.3904/kjim.2016.323.

Management of carbapenem-resistant Acinetobacter baumannii epidemic in an intensive care unit using multifaceted intervention strategy

Affiliations
  • 1Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea. zenmd@naver.com
  • 2Infection Control Office, Gyeongsang National University Hospital, Jinju, Korea.
  • 3Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
  • 4Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Abstract

BACKGROUND/AIMS
We evaluated the effects of a multifaceted intervention for controlling a carbapenem-resistant Acinetobacter baumannii (CRAB) epidemic in an intensive care unit (ICU) with no restrictions on carbapenem use.
METHODS
This study was conducted in a medical ICU between April 2012 and June 2016. The baseline infection control programs included surveillance cultures, contact precautions, and environmental cleaning. However, increases in the detection of CRAB isolates beginning in May 2013 led to the implementation of a new protocol, consisting of universal glove and gown use with daily chlorhexidine bathing for all patients in combination with baseline programs. The efficacy of the intervention was subjected to interrupted time series (ITS) analysis.
RESULTS
The multifaceted intervention led to a decrease in the incidence of CRAB from 17.65 to 0.89 cases per 1,000 patient-days, during the study period (p < 0.001). ITS analysis revealed a significant change in the trend of CRAB incidence (-0.413, p < 0.001). Over this same period, mean monthly use of carbapenems increased from 143.54 ± 95.73 to 204.95 ± 78.43 doses per 1,000 patient-days (p = 0.018).
CONCLUSIONS
Our multifaceted intervention reduced the incidence of CRAB acquisition in an ICU where carbapenem use was not restricted.

Keyword

Acinetobacter baumannii; Carbapenem resistance; Chlorhexidine; Intensive care units

MeSH Terms

Acinetobacter baumannii*
Acinetobacter*
Baths
Carbapenems
Chlorhexidine
Critical Care*
Drug Resistance, Bacterial
Humans
Incidence
Infection Control
Intensive Care Units*
Interrupted Time Series Analysis
Carbapenems
Chlorhexidine
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