J Dent Anesth Pain Med.  2018 Aug;18(4):245-254. 10.17245/jdapm.2018.18.4.245.

Analysis of the effect of oral midazolam and triazolam premedication before general anesthesia in patients with disabilities with difficulty in cooperation

Affiliations
  • 1Department of Dental Anesthesiology, Seoul National University, School of Dentistry, Seoul, Korea. stone90@snu.ac.kr
  • 2Department of Dental Anesthesiology, Seoul National University Dental Hospital, Seoul, Korea.
  • 3Special Care Clinic, Seoul National University Dental Hospital, Seoul, Korea.
  • 4Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, Seoul, Korea.

Abstract

BACKGROUND
When performing dental treatment under general anesthesia in adult patients who have difficulty cooperating due to intellectual disabilities, anesthesia induction may be difficult as well. In particular, patients who refuse to come into the dental office or sit in the dental chair may have to be forced to do so. However, for adult patients with a large physique, physical restraint may be difficult, while oral sedatives as premedication may be helpful. Here, a retrospective analysis was performed to investigate the effect of oral sedatives.
METHODS
A hospital-based medical information database was searched for patients who were prescribed oral midazolam or triazolam between January 2009 and December 2017. Pre-anesthesia evaluation, anesthesia, and anesthesia recovery records of all patients were analyzed, and information on disability type, reason for prescribing oral sedatives, prescribed medication and dose, cooperation level during anesthesia induction, anesthesia duration, length of recovery room stay, and complications was retrieved.
RESULTS
A total of 97 patients were identified, of whom 50 and 47 received midazolam and triazolam, respectively. The major types of disability were intellectual disabilities, autism, Down syndrome, blindness, cerebral palsy, and epilepsy. Analyses of changes in cooperation levels after drug administration showed that anesthesia induction without physical restraint was possible in 56.0% of patients in the midazolam group and in 46.8% of patients in the triazolam group (P = 0.312).
CONCLUSIONS
With administration of oral midazolam or triazolam, general anesthesia induction without any physical restraint was possible in approximately 50% of patients, with no difference between the drugs.

Keyword

Dental Treatment; General Anesthesia; Intellectual Disability; Midazolam; Sedative Premedication; Triazolam

MeSH Terms

Adult
Anesthesia
Anesthesia, General*
Autistic Disorder
Blindness
Cerebral Palsy
Dental Offices
Down Syndrome
Epilepsy
Humans
Hypnotics and Sedatives
Intellectual Disability
Midazolam*
Premedication*
Recovery Room
Restraint, Physical
Retrospective Studies
Triazolam*
Hypnotics and Sedatives
Midazolam
Triazolam

Figure

  • Fig. 1 A flow chart of the study population is presented (MDZ = midazolam, TZ = triazolam).

  • Fig. 2 Relationship between cooperation level and dose per weight (kg) of midazolam and triazolam


Cited by  1 articles

Difficult intubation caused by an immature upper airway in a patient with cri-du-chat syndrome: a case report
Eunsun So, Seungoh Kim
J Dent Anesth Pain Med. 2020;20(1):49-53.    doi: 10.17245/jdapm.2020.20.1.49.


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