J Korean Ophthalmol Soc.  2018 Aug;59(8):724-729. 10.3341/jkos.2018.59.8.724.

Anti-pseudomonal Effect of a Nephrite-containing Contact Lens Storage Case

Affiliations
  • 1Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. jiel75@hanmail.net
  • 2Department of Parasitology and Tropical Medicine, Pusan National University School of Medicine, Yangsan, Korea.
  • 3Department of Optometry, Busan Women's College, Busan, Korea.
  • 4Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.

Abstract

PURPOSE
To compare the anti-pseudomonal effect of nephrite-containing contact lens (CL) storage cases with conventional CL storage cases.
METHODS
The degree of proliferation and adhesion of Pseudomonas aeruginosa (P. aeruginosa) on 1st-3rd generation silicone hydrogel contact lenses (SHCLs) was compared by using both 5% nephrite-containing CL storage cases and conventional CL storage cases. The degree of adhesion of P. aeruginosa to the CL was also compared in 1% or 5% nephrite solution and multipurpose solution (MPS).
RESULTS
Nephrite-containing CL storage cases showed a significant inhibitory effect on P. aeruginosa proliferation (p = 0.03) and significantly reduced the number of adherent P. aeruginosa on all 1st-3rd generation SHCLs compared with conventional CL storage cases (p = 0.02, p = 0.03, and p < 0.01, respectively). There was no significant anti-pseudomonal effect of 1% and 5% nephrite solutions compared with MPS.
CONCLUSIONS
Nephrite may be the next generation substance that reduces infectious keratitis caused by P. aeruginosa when added to CL storage cases.

Keyword

Contact lens storage case; Infectious keratitis; Multipurpose solution; Nephrite; Pseudomonas aeruginosa

MeSH Terms

Contact Lenses
Hydrogel
Keratitis
Pseudomonas aeruginosa
Silicon
Silicones
Hydrogel
Silicon
Silicones
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