Ewha Med J.  2018 Jul;41(3):45-52. 10.12771/emj.2018.41.3.45.

Comparison of Clinical Manifestation and Laboratory Findings between Adenoviral Infection with or without Kawasaki Disease

Affiliations
  • 1Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea. ymhong@ewha.ac.kr

Abstract


OBJECTIVES
Adenovirus infection, which has been known to mimic Kawasaki disease (KD), is one of the most frequent conditions observed during differential diagnosis when considering KD. Accordingly, it is essential to being able to differentiate between these two diseases. Therefore, we performed multiplex reverse transcriptase-polymerase chain reaction and tissue-Doppler echocardiography to distinguish between adenovirus patients and KD patients.
METHODS
A total of 113 adenoviral infection patients (female 48, male 65) diagnosed from January 2010 to June 2016 were evaluated. We divided adenoviral infection patients into two groups: group 1, which consisted of individuals diagnosed with KD according to the KD American Heart Association criteria (n=62, KD with adenovirus infection); and group 2, which comprised individuals only diagnosed with adenovirus infection (n=51). Laboratory data were obtained from each patient including N-terminal pro-brain natriuretic peptide. Echocardiographic measurements were compared between two groups. In addition, reverse transcriptase-polymerase chain reaction was performed using nasopharyngeal secretions to diagnose adenoviral infection.
RESULTS
Conjunctival injection, cervical lymphadenopathy, polymorphous skin rash, abnormalities of the lip or oral mucosa and abnormalities of extremities were significantly higher in group 1 than group 2. Moreover, group 1 had significantly higher C-reactive protein and alanine aminotransferase levels, as well as lower platelet counts and albumin levels than group 2. Coronary artery diameter was significantly greater in group 1 than group 2.
CONCLUSION
In patients with adenoviral infection with unexplained prolonged fever, echocardiography and C-reactive protein can be used to differentiate KD with adenoviral infection from adenoviral infection alone.

Keyword

Mucocutaneous lymph node syndrome; Adenoviridae; Polymerase chain reaction; Echocardiography

MeSH Terms

Adenoviridae
Adenoviridae Infections
Alanine Transaminase
American Heart Association
C-Reactive Protein
Coronary Vessels
Diagnosis, Differential
Echocardiography
Exanthema
Extremities
Fever
Humans
Lip
Lymphatic Diseases
Male
Mouth Mucosa
Mucocutaneous Lymph Node Syndrome*
Platelet Count
Polymerase Chain Reaction
Alanine Transaminase
C-Reactive Protein
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