J Neurogastroenterol Motil.
2018 Jan;24(1):87-95. 10.5056/jnm16216.
Increased Postprandial Colonic Motility and Autonomic Nervous System Activity in Patients With Irritable Bowel Syndrome: A Prospective Study
- Affiliations
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- 1Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. y-tanaka@med.tohoku.ac.jp
- 2Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
- 3Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, NC, USA.
- KMID: 2417276
- DOI: http://doi.org/10.5056/jnm16216
Abstract
- BACKGROUND/AIMS
The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV is correlated with colonic motility and IBS symptoms.
METHODS
One hundred and fifty-six Rome III positive IBS patients and 31 healthy controls underwent colonic manometry with bag distention in the descending colon, followed by ingestion of an 810-kcal meal. HRV, evaluated by low frequency (%LF; 0.04-0.15 Hz) component, high frequency (%HF; 0.15-0.40 Hz) component, and the LF/HF ratio, was measured during colonic distention and after the meal. Motility index and subjective symptom scores were simultaneously quantified.
RESULTS
Both colonic distention and eating decreased %HF and increased the LF/HF ratio, and both indices of autonomic nervous system correlated with age. In IBS patients, %HF negatively correlated with the postprandial motility index after adjusting for age. The %HF and LF/HF ratios also correlated with psychological symptoms but not bowel symptoms in IBS patients.
CONCLUSION
Decreased vagal activity is associated with increase in age and greater postprandial colonic motility in patients with IBS, which may contribute to postprandial symptoms.
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