Yeungnam Univ J Med.  2018 Jun;35(1):40-44. 10.12701/yujm.2018.35.1.40.

Effect of preoperative pregabalin on postoperative pain after gastrectomy

• Park CY
• Park SH
• Lim DG
• Choi EK

• KMID: 2415732
• DOI: http://doi.org/10.12701/yujm.2018.35.1.40

Abstract

BACKGROUND
Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of pregabalin in resolving post-gastrectomy pain.
METHODS
Forty-four patients were randomized into two groups: a pregabalin group that received oral pregabalin (150 mg) 2 h before anesthetic induction, and a control group that received placebo tablets at the same time. Data on postoperative pain intensity (visual analog scale [VAS], at 30 min, 2 h, 4 h, and 24 h), consumption of fentanyl in patient-controlled analgesia (PCA), and the proportion of patients requiring rescue analgesics at different time intervals (0-2 h, 2-4 h, and 4-24 h) were collected during the 24 h postoperative period.
RESULTS
The VAS scores did not show significant differences at any time point and consumption of fentanyl in PCA and the proportion of patients requiring rescue analgesics did not differ between the two groups. The groups did not differ in the occurrence of dizziness, sedation, and dry mouth.
CONCLUSION
A preoperative 150 mg dose of pregabalin exerts no effect on acute pain after gastrectomy.

Keyword

Pregabalin; Postoperative pain; Gastrectomy

MeSH Terms

Acute Pain
Analgesia, Patient-Controlled
Analgesics
Dizziness
Fentanyl
Gastrectomy*
Humans
Mouth
Pain, Postoperative*
Passive Cutaneous Anaphylaxis
Postoperative Period
Pregabalin*
Tablets
Analgesics
Fentanyl
Pregabalin
Tablets

Figure

• 

  Fig. 1. VAS score changes in both groups at postoperative 30 min, 2 h, 4 h, and 24 h . VAS, visual analog scale; group C, control group; group P, pregabalin group.

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