Clin Exp Otorhinolaryngol.  2014 Jun;7(2):102-105.

The Efficacy of Preemptive Analgesia With Pregabalin in Septoplasty

• Kim JH
• Seo MY
• Hong SD
• Lee J
• Chung SK
• Kim HY
• Dhong HJ

Abstract

OBJECTIVES
Pregabalin is used to treat neuropathic pain and has shown analgesic properties in postoperative pain. The aim of this study was to investigate the effectiveness and safety of pregabalin in reducing postoperative pain in patients after septoplasty.
METHODS
Forty-seven patients scheduled for elective septoplasty were randomly assigned to groups that received either pregabalin (150 mg) or placebo, both one hour before surgery and 12 hours after the initial dose. Pain (verbal numerical rating scale, VNRS) and side effect assessments were performed at 6, 12, 12 to 24, and 24 to 48 hours postoperatively.
RESULTS
From 1 to 12 hours postoperatively, VNRS scores for pain were lower in the pregabalin group (n=24) than in the placebo group (n=23; P<0.05). The number of patients who needed rescue analgesics was lower in the pregabalin group (P=0.042). The incidence of nausea and vomiting did not differ between groups (P=0.666), and the incidence of sedation was higher in the placebo groups (P=0.022).
CONCLUSION
The perioperative administration of oral pregabalin (150 mg twice) is an effective and safe way to reduce early postoperative pain in patients undergoing septoplasty.

Keyword

Postoperative pain; Pregabalin; Septoplasty; Preemptive analgesia

MeSH Terms

Analgesia*
Analgesics
Humans
Incidence
Nausea
Neuralgia
Pain, Postoperative
Vomiting
Pregabalin
Analgesics

Figure

• 

  Fig. 1 Verbal numerical rating scale (VNRS) for pain at rest in placebo and pregabalin groups at 6, 12, 12 to 24, and 24 to 48 hours after surgery and after packing was removed. Spearman partial correlation analysis with Bonferroni correction. Values are median±quartile range. *P<0.05 compared with placebo.

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