Clin Exp Otorhinolaryngol.  2014 Jun;7(2):102-105.

The Efficacy of Preemptive Analgesia With Pregabalin in Septoplasty

Affiliations
  • 1Department of Rhinology, HANA ENT HOSPITAL, Seoul, Korea.
  • 2Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hjdhong@skku.ed

Abstract


OBJECTIVES
Pregabalin is used to treat neuropathic pain and has shown analgesic properties in postoperative pain. The aim of this study was to investigate the effectiveness and safety of pregabalin in reducing postoperative pain in patients after septoplasty.
METHODS
Forty-seven patients scheduled for elective septoplasty were randomly assigned to groups that received either pregabalin (150 mg) or placebo, both one hour before surgery and 12 hours after the initial dose. Pain (verbal numerical rating scale, VNRS) and side effect assessments were performed at 6, 12, 12 to 24, and 24 to 48 hours postoperatively.
RESULTS
From 1 to 12 hours postoperatively, VNRS scores for pain were lower in the pregabalin group (n=24) than in the placebo group (n=23; P<0.05). The number of patients who needed rescue analgesics was lower in the pregabalin group (P=0.042). The incidence of nausea and vomiting did not differ between groups (P=0.666), and the incidence of sedation was higher in the placebo groups (P=0.022).
CONCLUSION
The perioperative administration of oral pregabalin (150 mg twice) is an effective and safe way to reduce early postoperative pain in patients undergoing septoplasty.

Keyword

Postoperative pain; Pregabalin; Septoplasty; Preemptive analgesia

MeSH Terms

Analgesia*
Analgesics
Humans
Incidence
Nausea
Neuralgia
Pain, Postoperative
Vomiting
Pregabalin
Analgesics

Figure

  • Fig. 1 Verbal numerical rating scale (VNRS) for pain at rest in placebo and pregabalin groups at 6, 12, 12 to 24, and 24 to 48 hours after surgery and after packing was removed. Spearman partial correlation analysis with Bonferroni correction. Values are median±quartile range. *P<0.05 compared with placebo.


Reference

1. Dubin MR, Pletcher SD. Postoperative packing after septoplasty: is it necessary. Otolaryngol Clin North Am. 2009; 4. 42(2):279–285. PMID: 19328892.
Article
2. Dahl JB, Mathiesen O, Moiniche S. 'Protective premedication': an option with gabapentin and related drugs? A review of gabapentin and pregabalin in in the treatment of post-operative pain. Acta Anaesthesiol Scand. 2004; 10. 48(9):1130–1136. PMID: 15352959.
3. Agarwal A, Gautam S, Gupta D, Agarwal S, Singh PK, Singh U. Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. Br J Anaesth. 2008; 11. 101(5):700–704. PMID: 18716003.
Article
4. Jokela R, Ahonen J, Tallgren M, Haanpaa M, Korttila K. A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy. Pain. 2008; 1. 134(1-2):106–112. PMID: 17507163.
Article
5. Jokela R, Ahonen J, Tallgren M, Haanpaa M, Korttila K. Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br J Anaesth. 2008; 6. 100(6):834–840. PMID: 18448418.
Article
6. Kim SY, Jeong JJ, Chung WY, Kim HJ, Nam KH, Shim YH. Perioperative administration of pregabalin for pain after robot-assisted endoscopic thyroidectomy: a randomized clinical trial. Surg Endosc. 2010; 11. 24(11):2776–2781. PMID: 20376496.
Article
7. Kim SY, Song JW, Park B, Park S, An YJ, Shim YH. Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study. Acta Anaesthesiol Scand. 2011; 3. 55(3):290–296. PMID: 21288209.
Article
8. Mathiesen O, Jacobsen LS, Holm HE, Randall S, Adamiec-Malmstroem L, Graungaard BK, et al. Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty. Br J Anaesth. 2008; 10. 101(4):535–541. PMID: 18653493.
Article
9. Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature. 1983; 12. 306(5944):686–688. PMID: 6656869.
Article
10. Turan A, Memis D, Karamanlioglu B, Yagiz R, Pamukcu Z, Yavuz E. The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesth Analg. 2004; 8. 99(2):375–378. PMID: 15271709.
Article
11. Reuben SS, Buvanendran A, Kroin JS, Raghunathan K. The analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery. Anesth Analg. 2006; 11. 103(5):1271–1277. PMID: 17056968.
12. Freedman BM, O'Hara E. Pregabalin has opioid-sparing effects following augmentation mammaplasty. Aesthet Surg J. 2008; Jul-Aug. 28(4):421–424. PMID: 19083556.
Article
13. Mathiesen O, Rasmussen ML, Dierking G, Lech K, Hilsted KL, Fomsgaard JS, et al. Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy: a randomized clinical trial. Acta Anaesthesiol Scand. 2009; 2. 53(2):227–235. PMID: 19076108.
Article
14. Mathiesen O, Moiniche S, Dahl JB. Gabapentin and postoperative pain: a qualitative and quantitative systematic review, with focus on procedure. BMC Anesthesiol. 2007; 7. 7:6. PMID: 17617920.
Article
15. Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg. 2007; 6. 104(6):1545–1556. PMID: 17513656.
Article
16. Gilron I. Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions. Curr Opin Anaesthesiol. 2007; 10. 20(5):456–472. PMID: 17873599.
Article
17. Kavoussi R. Pregabalin: from molecule to medicine. Eur Neuropsychopharmacol. 2006; 7. 16(Suppl 2):S128–S133. PMID: 16765030.
Article
Full Text Links
  • CEO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr