Infect Chemother.  2018 Jun;50(2):153-159. 10.3947/ic.2018.50.2.153.

Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review

  • 1Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 2Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 3Catholic Hematology Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.


Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five patients who developed cytomegalovirus (CMV) colitis during dasatinib treatment, in whom the colitis was initially confused with other causes. The patients, three with chronic myeloid leukemia, and two with acute lymphoblastic leukemia, were diagnosed with CMV colitis based on endoscopic and histologic findings. The patients who examined blood CMV polymerase chain reaction were all positive. The patients received antiviral therapy in the form of either ganciclovir or valganciclovir, and the overall treatment outcome was fair. These cases suggest that physicians should consider the possibility of CMV reactivation when treating diarrhea and/or hematochezia in patients on dasatinib.


Cytomegalovirus; Colitis; Dasatinib

MeSH Terms

Gastrointestinal Hemorrhage
Hematologic Neoplasms*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Treatment Outcome
Protein-Tyrosine Kinases


  • Figure 1 Colonoscopic finding of cytomegalovirus colitis (A) patient 1, edematous mucosa, friability, loss of vascularity. (B) patient 2, multiple erythema and shallow ulceration. (C) patient 4, edematous mucosa and shallow erosion. (D) patient 5, mild erythema, ulceration with blood clot

  • Figure 2 Pathologic finding of cytomegalovirus colitis: positive immunohistochemistry for cytomegalovirus (red arrow) (×100)


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