J Korean Assoc Oral Maxillofac Surg.  2018 Jun;44(3):103-106. 10.5125/jkaoms.2018.44.3.103.

Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, Kannur Dental College, Anjarakandy Integrated Campus, Kannur, India.
  • 2Department of Oral and Maxillofacial Surgery and Dentistry, Malankara Orthodox Syrian Church Medical College & Hospital, Kolenchery, Kochi, India. sureshvyloppilli@gmail.com
  • 3Department of Cleft and Craniomaxillofacial Surgery, Aster MIMS Hospital, Calicut, India.
  • 4Department of Craniomaxillofacial Surgery, Amrita School of Dentistry, Kochi, India.
  • 5Department of Oral and Maxillofacial Surgery, KMCT Dental College, Calicut, India.

Abstract


OBJECTIVES
The goal of the study was to investigate the clinical effects of amoxicillin-clavulanic acid (500+125 mg) with metronidazole 400 mg administered three times daily (Group I) versus azithromycin 500 mg administered once daily and with metronidazole 400 mg three times daily (Group II) for the prevention of postoperative infection following mandibular third molar surgical removal.
MATERIALS AND METHODS
The study design was a single-center prospective study. Patients who reported to the Department of Oral and Maxillofacial Surgery between February 2015 and January 2017 for removal of mandibular third molar were screened, and 108 patients were chosen. One surgeon carried out all procedures. Patients were prescribed antibiotics until the two groups contained a similar number of cases.
RESULTS
Our data showed that Group II had fewer incidences of surgical site infection, but with no statistical significance.
CONCLUSION
Although both treatments are used routinely after removal of the mandibular third molar, neither is significantly better than the other.

Keyword

Impacted third molar removal; Antibiotic prophylaxis; Amoxicillin; Azithromycin; Metronidazole

MeSH Terms

Amoxicillin
Amoxicillin-Potassium Clavulanate Combination*
Anti-Bacterial Agents
Antibiotic Prophylaxis
Azithromycin*
Humans
Incidence
Metronidazole*
Molar, Third*
Prospective Studies
Surgery, Oral
Surgical Wound Infection
Amoxicillin
Amoxicillin-Potassium Clavulanate Combination
Anti-Bacterial Agents
Azithromycin
Metronidazole

Figure

  • Fig. 1 Description of patients with surgical site infection under an antibiotic regimen.


Cited by  1 articles

Antibiotic sensitivity and resistance of bacteria from odontogenic maxillofacial abscesses
Sang-Hoon Kang, Moon-Key Kim
J Korean Assoc Oral Maxillofac Surg. 2019;45(6):324-331.    doi: 10.5125/jkaoms.2019.45.6.324.


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