J Gynecol Oncol.  2017 May;28(3):e35. 10.3802/jgo.2017.28.e35.

Increased risk of breast cancer in women with uterine myoma: a nationwide, population-based, case-control study

  • 1Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • 2Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. epid@vghtc.gov.tw


To evaluate if uterine myoma is associated with breast cancer.
This case-control study used a nationwide database in Taiwan. We identified 24,315 patients with newly diagnosed breast cancer as cases and matched them with 24,281 patients without breast cancer on age, sex, urbanization, income, and initial diagnosis date. Patients with prior mastectomy were excluded. We used logistic regression analysis to assess the association between uterine myoma and breast cancer while adjusting for confounders. We evaluated the impact of surgical removal of uterine myoma on subsequent breast cancer among patients with uterine myoma.
We found that 2,892 (11.9%) patients with newly diagnosed breast cancer and 2,541 (10.5%) patients without breast cancer had a history of uterine myoma. The association between breast cancer and uterine myoma was significant (adjusted odds ratio [aOR]=1.14; 95% confidence interval [CI]=1.07-1.21; p<0.001). This association remained in patients who used hormone (aOR=1.20; 95% CI=1.08-1.33; p=0.001) or who did not use hormone (aOR=1.11; 95% CI=1.03-1.19; p=0.005) within 5 years prior to the index date. Surgical removal of uterine myoma was not associated with a decreased risk of breast cancer (aOR=0.99; 95% CI=0.88-1.10; p=0.795).
A minor increased risk of breast cancer was found in women with a history of uterine myoma. This association remained in patients with recent hormone use. Removal of uterine myoma was not associated with decreased risk of breast cancer.


Uterus; Leiomyoma; Breast Neoplasms; Hormone Replacement Therapy; Case-Control Studies; National Health Programs

MeSH Terms

Breast Neoplasms/complications/*epidemiology
Case-Control Studies
Logistic Models
Middle Aged
Population Surveillance
Risk Factors
Uterine Neoplasms/complications/*epidemiology/surgery


  • Fig. 1. Flowchart of selection process of study population. ICD-9-CM, International Classification of Diseases, 9th revision, clinical modification; NHIRD, National Health Insurance Research Database; UM, uterine myoma.

Cited by  1 articles

Prior uterine myoma and risk of ovarian cancer: a population-based case-control study
Jenn-Jhy Tseng, Chun-Che Huang, Hsiu-Yin Chiang, Yi-Huei Chen, Ching-Heng Lin
J Gynecol Oncol. 2019;30(5):.    doi: 10.3802/jgo.2019.30.e72.



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