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Machine Learning and Deep Learning for the Pharmacogenomics of Antidepressant Treatments

Lin E, Lin CH, Lane HY

A growing body of evidence now proposes that machine learning and deep learning techniques can serve as a vital foundation for the pharmacogenomics of antidepressant treatments in patients with major...
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Novel Biomarkers of Alzheimer’s Disease: Based Upon N-methylD-aspartate Receptor Hypoactivation and Oxidative Stress

Chiang TI, Yu YH, Lin CH, Lane HY

Early detection and prevention of Alzheimer's disease (AD) is important. The current treatment for early AD is acetylcholine esterase inhibitors (AChEIs); however, the efficacy is poor. Besides, AChEI did not...
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In Reply: Trough Melatonin Levels Have No Physiological or Clinical Relevance

Lin CH, Lane HY

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Trough Melatonin Levels Differ between Early and Late Phases of Alzheimer Disease

Lin CH, Chiu CC, Lane HY

Objective: Melatonin has been considered to have an essential role in the pathophysiology of Alzheimer’s disease (AD) for its regulatory function on circadian rhythm and interaction with glutamate for the...
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Antipsychotic Medication in Schizophrenic Patients is Associated with Higher Risks of Developing Bone Fractures and Refractures

Kuo CM, Liao WJ, Huang CC, Lan TH, Lin CH, Wang SP, Lee CH, Lui PW

Objective: The relationship of antipsychotics and the risk of refracture in treated patients is unclear. The aim of this study is to evaluate the association between prolonged antipsychotic and the...
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Admission policies and methods at crossroads: a review of medical school admission policies and methods in seven Asian countries

Soemantri D, Karunathilake I, Yang JH, Chang SC, Lin CH, Nadarajah VD, Nishigori H, Samarasekera DD, Lee SS, Tanchoco LR, Ponnamperuma G

Selecting the right applicants is an important part of medical student admission. While one universally accepted selection criterion is academic capacity, there are other criteria such as communication skills and...
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Management of Hyperacute Stroke during the Coronavirus Disease of 2019 Pandemic: The Modified Code Stroke in a Medical Center in Taiwan

Lin PY, Chang YM, Huang CY, Lin CH, Chuang MT, Chen PL, Sung PS, Chen CH

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Response to comment on: prior uterine myoma and risk of ovarian cancer: a population-based case-control study

Huang CC, Lin CH

No abstract available.
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Prior uterine myoma and risk of ovarian cancer: a population-based case-control study

Tseng JJ, Huang CC, Chiang HY, Chen YH, Lin CH

OBJECTIVE: Uterine myoma which results in the magnitude of ovarian cancer remains uncertain. This study aimed to assess the association between women with previous uterine myoma and the risk of...
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Doxorubicin Promotes Migration and Invasion of Breast Cancer Cells through the Upregulation of the RhoA/MLC Pathway

Liu CL, Chen MJ, Lin JC, Lin CH, Huang WC, Cheng SP, Chen SN, Chang YC

PURPOSE: Cancer cells develop acquired resistance induced by chemotherapeutic drugs. In this study, we investigated the effects of brief treatment with cytotoxic drugs on the phenotype of breast cancer cells. METHODS:...
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Altered Gut Microbiome and Intestinal Pathology in Parkinson's Disease

Chiang HL, Lin CH

Parkinson's disease (PD) is a common neurodegenerative disorder arising from an interplay between genetic and environmental risk factors. Studies have suggested that the pathological hallmarks of intraneuronal α-synuclein aggregations may...
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Role of Salivary Immune Parameters in Patients With Primary Sjögren's Syndrome

Hung YH, Lee YH, Chen PP, Lin YZ, Lin CH, Yen JH

BACKGROUND: Several factors, including clinical manifestations and laboratory data, have been used to evaluate the disease activity of Sjögren's syndrome (SS). We investigated saliva indicators of disease activity in primary...
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The development of Taiwan Fracture Liaison Service network

Chang LY, Tsai KS, Peng JK, Chen CH, Lin GT, Lin CH, Tu ST, Mao IC, Gau YL, Liu HC, Niu CC, Hsieh MH, Chien JT, Hung WC, Yang RS, Wu CH, Chan DC

Osteoporosis and its associated fragility fractures are becoming a severe burden in the healthcare system globally. In the Asian-Pacific (AP) region, the rapidly increasing in aging population is the main...
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Health Care Utilization and Expenditures of Patients with Diabetes Comorbid with Depression Disorder: A National Population-Based Cohort Study

Huang CJ, Hsieh HM, Chiu HC, Wang PW, Lee MH, Li CY, Lin CH

OBJECTIVE: The study investigated to compare health care utilization and expenditures between diabetic patients with and without depression in Taiwan. METHODS: Health care utilization and expenditure among diabetic patients with and...
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Increased risk of breast cancer in women with uterine myoma: a nationwide, population-based, case-control study

Tseng JJ, Chen YH, Chiang HY, Lin CH

OBJECTIVE: To evaluate if uterine myoma is associated with breast cancer. METHODS: This case-control study used a nationwide database in Taiwan. We identified 24,315 patients with newly diagnosed breast cancer as...
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Venous Thromboembolism Following Dantrolene Treatment for Neuroleptic Malignant Syndrome

Chen PH, Lane HY, Lin CH

Neuroleptic malignant syndrome (NMS) is one of the most severe iatrogenic emergencies in clinical service. The symptoms including sudden consciousness change, critical temperature elevation and electrolytes imbalance followed by mutli-organ...
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Effects of Antipsychotics on Bone Mineral Density in Patients with Schizophrenia: Gender Differences

Chen CY, Lane HY, Lin CH

Low bone mineral density (BMD) and osteoporosis are common in patients with schizophrenia and detrimental to illness prognosis and life quality. Although the pathogenesis is not fully clear, series of...
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Association between IPTA Gene Polymorphisms and Hematological Abnormalities in Hepatitis C Virus-Infected Patients Receiving Combination Therapy

Hwang JJ, Lo CC, Lin CH, Cheng HS, Hung IW, Tsai WJ, Hung CH

BACKGROUND/AIMS: Hematological abnormalities during hepatitis C virus (HCV) combination therapy with pegylated interferon alpha and ribavirin often necessitate dose reduction. Variants of the ITPA gene have been reported to protect...
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Statin Therapy for Primary Prevention of Atrial Fibrillation: Guided by CHADS2/CHA2DS2VASc Score

Hung CY, Hsieh YC, Huang JL, Lin CH, Wu TJ

Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased cardiovascular morbidity and mortality. The anti-arrhythmic effect of statins on AF prevention appears to be highly significant...
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Erratum

Wong HL, Chen MC, Wu CS, Fu KA, Lin CH, Weng MJ, Liang HL, Pan HB

The publisher and authors would like to draw the reader's attention to an error in the following article. The Usefulness of Fast-Spin-Echo T2-Weighted MR Imaging in Nutcracker Syndrome: a Case...
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