Allergy Asthma Immunol Res.  2017 Mar;9(2):182-184. 10.4168/aair.2017.9.2.182.

Fixed Food Eruption Caused by Actinidia arguta (Hardy Kiwi): A Case Report and Literature Review

• Sohn KH
• Kim BK
• Kim JY
• Song WJ
• Kang HR
• Park HW
• Cho SH
• Min KU

• KMID: 2413393
• DOI: http://doi.org/10.4168/aair.2017.9.2.182

Abstract

Fixed drug eruption (FDE) is a common hypersensitivity reaction characterized by recurrent, well-circumscribed, erythematous patches that arise at the same site as a result of systemic drug exposure. However, fixed food eruption (FFE), a lesion triggered by food ingestion, is a rare allergy that was first defined in 1996. Based on their anti-inflammatory and anti-oxidant properties, the fruit and leaves of Actinidia arguta, the hardy kiwi, are widely consumed across Korea, Japan, and China. This report describes the first case of FFE caused by hardy kiwi leaves, known as Daraesun in Korean, confirmed by oral provocation tests and skin biopsy.

Keyword

Fixed food eruption; actinidia arguta; food allergy

MeSH Terms

Actinidia*
Biopsy
China
Drug Eruptions
Eating
Food Hypersensitivity
Fruit
Hypersensitivity
Japan
Korea
Skin

Figure

• 

  Fig. 1 (A) Actinidia arguta (hardy kiwi) vegetable. (B) The larger Actinidia deliciosa (green kiwi fruit) in back compared to the Actinidia arguta in front (cited image from: https://en.wikipedia.org/wiki/Actinidia_arguta). (C) Boiled Actinidia arguta vegetable for oral provocation tests.

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  Fig. 2 (A) Recurrent localized erythemas with hyperpigmentation on the patient’s right wrist. (B, C) Twenty-four hours after Actinidia arguta oral provocation test (B, typical fixed eruption on the wrist; C, perioral eruption with contact dermatitis).

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  Fig. 3 (A) Superficial perivascular lymphocytic and slightly eosinophilic infiltration with increased dermal melanophages by hematoxylin-and-eosin staining (×200). (B) The immunohistochemical staining shows the intraepidermal CD8+ T cells resident in the skin lesion (×400).

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