Clin Psychopharmacol Neurosci.  2018 May;16(2):228-231. 10.9758/cpn.2018.16.2.228.

Quetiapine Related Acute Paralytic Ileus in a Bipolar I Disorder Patient with Successful Low Dose Amisulpride Substitution: A Case Report

• Chiang ST
• Lan CC

• KMID: 2412395
• DOI: http://doi.org/10.9758/cpn.2018.16.2.228

Abstract

The mechanism of medication-induced gastrointestinal hypomotility is primarily caused by muscarinic cholinergic antagonism. This effect may cause constipation and paralytic ileus, which may lead to fatal complications. A 51-year-old woman was admitted due to manic episode recurrence. She developed paralytic ileus under quetiapine use and treated successfully under low dose amisulpride use. The related mechanism, associated risk factors, and the rationale for medication switch are discussed.

Keyword

Bipolar disorder; Paralytic ileus; Constipation; Quetiapine; Amisulpride; Anticholinergics

MeSH Terms

Bipolar Disorder
Cholinergic Antagonists
Constipation
Female
Humans
Intestinal Pseudo-Obstruction*
Middle Aged
Quetiapine Fumarate*
Recurrence
Risk Factors
Cholinergic Antagonists
Quetiapine Fumarate