Gut Liver.  2017 May;11(3):377-382. 10.5009/gnl16211.

Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett's Esophagus

• Lee SW
• Lien HC
• Lee TY
• Tung CF
• Yeh HZ
• Chang CS

• KMID: 2412211
• DOI: http://doi.org/10.5009/gnl16211

Abstract

BACKGROUND/AIMS
The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett's esophagus (BE) in a Chinese population.
METHODS
Data from subjects were retrospectively collected from 2006 to 2009. Individuals with BE were identified and age- and sex-matched at a 1:2 ratio with normal esophagocardial junction and EE patients. The subjects were stratified into two groups: the normal weight group and overweight/obesity group (body mass index ≥25 mg/m²) or the normal waist group and abdominal obesity group (waist circumference ≥90 cm for men and ≥80 cm for women).
RESULTS
Overall, 45%, 72%, and 52% were overweight/obese and 23%, 65%, and 18% had abdominal obesity in the normal, EE, and BE groups, respectively. Positive associations were identified between EE and overweight/obesity (odds ratio [OR], 3.14; 95% confidence interval [CI], 1.75 to 5.66) and abdominal obesity (OR, 6.22; 95% CI, 3.34 to 11.57); however, the associations were nonsignificant between BE and overweight/obesity (OR, 1.32; 95% CI, 0.67 to 2.61) or abdominal obesity (OR, 0.73; 95% CI, 0.31 to 1.73). Female BE patients had a significantly increased rate of being overweight/obese.
CONCLUSIONS
Obesity is a contributing factor in EE. The association of BE and obesity was not significant, with the exception of female BE cases.

Keyword

Barrett esophagus; Gastroesophageal reflux; Obesity

MeSH Terms

Adult
Aged
Barrett Esophagus/*etiology/physiopathology
Case-Control Studies
China
Esophagitis/*etiology/physiopathology
Esophagus/physiopathology
Female
Humans
Male
Middle Aged
Obesity/*complications/physiopathology
Obesity, Abdominal/complications/physiopathology
Odds Ratio
Retrospective Studies
Risk Factors
Sex Factors