Tissue Eng Regen Med.
2017 Dec;14(6):735-742. 10.1007/s13770-017-0079-5.
Regenerative Potential of Platelet Rich Fibrin (PRF) for Curing Intrabony Periodontal Defects: A Systematic Review of Clinical Studies
- Affiliations
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- 1Restorative Dental Sciences Department, Al-Farabi Colleges, Riyadh 11313, Saudi Arabia.
- 2Biomedical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada.
- 3Department of Restorative Dentistry, College of Dentistry, Qassim University, Buraidah 51452, Saudi Arabia.
- 4Department of Oral Microbiology, Dow Dental College, Dow University of Health Sciences, Mission Road, Karachi 74200, Pakistan.
- 5Department of Restorative Dentistry, College of Dentistry, Taibah University, Al-Hezam Street, Al Madinah Al Munawwarah 41311, Saudi Arabia. drsohail_78@hotmail.com
- 6Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad 44000, Pakistan.
- 7Department of Dental Materials Science, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Pokfulam, Hong Kong.
- KMID: 2411867
- DOI: http://doi.org/10.1007/s13770-017-0079-5
Abstract
- Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. Recently, its use has been advocated for regenerative periodontics and wound healing. The randomized control trials have assessed the regenerative efficacy of the PRF for restoring intrabony periodontal defects.The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: "˜ platelet-rich fibrin', "˜ intrabony', "˜ periodontal', "˜ bone defect' and "˜ guided tissue regeneration'.Asecondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being included. Inmajority of studies, PRF resulted in better clinical/radiographic outcomes than open flap debridement and augmented therapeutic effects of bone grafts. The combination of bovine bone substitutes and PRF resulted in better performance compared to alone. Similarly better outcomes were observed while using PRF in combination with nanohydroxyapatite, metformin and demineralized freeze-dried bone allograft. It can be concluded that PRF produces better outcomes than open flap debridement alone and augments the regenerative effects of bone substitutes.
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