Korean J Intern Med.  2018 May;33(3):622-628. 10.3904/kjim.2016.046.

Baseline extent of damage predicts spinal radiographic progression in Korean patients with ankylosing spondylitis treated with golimumab

• Lee JS
• Song YW
• Kim TH
• Chung WT
• Lee SG
• Park SH
• Song GG
• Yu DY
• Xu S
• Lee EY

• KMID: 2411591
• DOI: http://doi.org/10.3904/kjim.2016.046

Abstract

BACKGROUND/AIMS
For patients with ankylosing spondylitis (AS), golimumab has consistent efficacy in controlling disease activity over 5 years but its benefit in preventing radiographic progression was less clear at 4 years. To predict radiographic progression, we analyzed the baseline characteristics of AS patients in a Korean population.
METHODS
Sixty-eight Korean patients with AS participated in the phase 3, multicenter, randomized, placebo-controlled, double-blind trial (GO-RAISE) which has previously been described. Baseline modified stoke AS spine score (mSASSS) and change in mSASSS from baseline (ΔmSASSS) until week 208 were analyzed in the Korean patients enrolled in the GO-RAISE study.
RESULTS
Although Korean patients had lower baseline mSASSS compared to non-Korean patients and received active management, radiographic progression was not prevented. Korean patients who did not undergo radiographic progression of spinal lesions of AS were younger and had shorter symptomatic duration, lower Bath AS functional and metrology indices, better chest expansion, and lower baseline mSASSS. The baseline mSASSS and ΔmSASSS were positively correlated in Korean AS patients (p < 0.001). Radiographic progression was more prevalent (80.0%) when baseline mSASSS > 10 and less common (13.0%) with baseline mSASSS = 0.
CONCLUSIONS
In Korean AS patients, radiographic progression of the spine after 4 years was predicted effectively by the initial severity of the spinal lesion(s) in patients treated with golimumab.

Keyword

Spondylitis, ankylosing; Golimumab; Disease progression

MeSH Terms

Baths
Disease Progression
Humans
Spine
Spondylitis, Ankylosing*
Thorax