Korean J Intern Med.
2018 Mar;33(2):256-276. 10.3904/kjim.2018.036.
Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea
- Affiliations
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- 1Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. symonlee@catholic.ac.kr
- 2The Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 3Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- KMID: 2411536
- DOI: http://doi.org/10.3904/kjim.2018.036
Abstract
- Hematopoietic stem cell transplantation (HSCT) is a treatment for hematologic malignancies, immune deficiencies, or genetic diseases, ect. Recently, the number of HSCTs performed in Korea has increased and the outcomes have improved. However, infectious complications account for most of the morbidity and mortality after HSCT. Post-HSCT infectious complications are usually classified according to the time after HSCT: pre-engraftment, immediate post-engraftment, and late post-engraftment period. In addition, the types and risk factors of infectious complications differ according to the stem cell source, donor type, conditioning intensity, region, prophylaxis strategy, and comorbidities, such as graft-versushost disease and invasive fungal infection. In this review, we summarize infectious complications after HSCT, focusing on the Korean perspectives.
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