J Obes Metab Syndr.  2018 Mar;27(1):53-60. 10.7570/jomes.2018.27.1.53.

Nonalcoholic Fatty Liver Disease and Abdominal Fat Accumulation According to Vitamin D Status in Patients with Type 2 Diabetes

• Choi DH
• Jung CH
• Mok JO
• Kim CH
• Kang SK
• Kim BY

• KMID: 2410876
• DOI: http://doi.org/10.7570/jomes.2018.27.1.53

Abstract

BACKGROUND
Vitamin D deficiency is known to increase the incidence of metabolic syndrome. Nonalcoholic fatty liver disease is a common metabolic disease in patients with type 2 diabetes. This study evaluated nonalcoholic fatty liver disease and abdominal fat accumulation according to 25-hydroxyvitamin D status in patients with type 2 diabetes.
METHODS
The study comprised 302 patients with type 2 diabetes. Patients were divided into three groups based upon their 25-hydroxyvitamin D status: vitamin D deficient group (<10 ng/mL), vitamin D insufficient group (≥10 to <20 ng/mL) and vitamin D sufficient group (≥20 ng/mL). Patient clinical and laboratory markers were evaluated retrospectively.
RESULTS
Visceral fat thickness was significantly higher in the vitamin D deficient group. There were no differences in glycemic control, body mass index, and subcutaneous fat thickness correlated with 25-hydroxyvitamin D status. The prevalence of nonalcoholic fatty liver disease was significantly higher in the vitamin D deficient group compared to the vitamin D sufficient and vitamin D insufficient groups. In multivariate logistic analysis, after adjustment for age, sex, body mass index, glycated hemoglobin and homeostasis model assessment of insulin resistance, patients with type 2 diabetes in the vitamin D sufficient group showed significantly lower odds ratio for nonalcoholic fatty liver disease than those within the vitamin D deficient group.
CONCLUSION
In type 2 diabetes, the vitamin D deficient group showed thicker visceral fat thickness and higher nonalcoholic fatty liver disease prevalence.

Keyword

Non-alcoholic fatty liver disease; Vitamin D; Type 2 diabetes mellitus

MeSH Terms

Abdominal Fat
Biomarkers
Body Mass Index
Diabetes Mellitus, Type 2
Hemoglobin A, Glycosylated
Homeostasis
Humans
Incidence
Insulin Resistance
Intra-Abdominal Fat
Metabolic Diseases
Non-alcoholic Fatty Liver Disease*
Odds Ratio
Prevalence
Retrospective Studies
Subcutaneous Fat
Vitamin D Deficiency
Vitamin D*
Vitamins*
Biomarkers
Vitamin D
Vitamins